ENSMUSG00000024411


Mus musculus

Features
Gene ID: ENSMUSG00000024411
  
Biological name :Aqp4
  
Synonyms : Aqp4 / aquaporin-4 isoform M1x
  
Possible biological names infered from orthology : aquaporin 4 / P55087
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 15389394
Gene end: 15403684
  
Corresponding Affymetrix probe sets: 10457614 (MoGene1.0st)   1425382_a_at (Mouse Genome 430 2.0 Array)   1434449_at (Mouse Genome 430 2.0 Array)   1447745_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078088
NCBI entrez gene - 11829     See in Manteia.
MGI - MGI:107387
RefSeq - NM_001308643
RefSeq - NM_001308644
RefSeq - NM_001308645
RefSeq - NM_001308646
RefSeq - NM_001308647
RefSeq - NM_001317729
RefSeq - NM_001308641
RefSeq - NM_001308642
RefSeq - NM_009700
RefSeq Peptide - NP_033830
RefSeq Peptide - NP_001295570
RefSeq Peptide - NP_001295571
RefSeq Peptide - NP_001295572
RefSeq Peptide - NP_001295573
RefSeq Peptide - NP_001295574
RefSeq Peptide - NP_001295575
RefSeq Peptide - NP_001295576
RefSeq Peptide - NP_001304658
swissprot - A0A0R4J0Z3
Ensembl - ENSMUSG00000024411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aqp4ENSDARG00000010565Danio rerio
 AQP4ENSGALG00000015128Gallus gallus
 AQP4ENSG00000171885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp5 / Q9WTY4 / Aquaporin-5 / P55064*ENSMUSG0000004421739
Aqp2 / P56402 / Aquaporin-2 / P41181*ENSMUSG0000002301338
Aqp1 / Q02013 / Aquaporin-1 / P29972* / AC004691.2* / aquaporin 1 (Colton blood group)*ENSMUSG0000000465537
Mip / P51180 / Lens fiber major intrinsic protein / P30301* / major intrinsic protein of lens fiber*ENSMUSG0000002538935
Aqp6 / Q8C4A0 / Aquaporin-6 / Q13520*ENSMUSG0000004314435
Aqp8 / P56404 / Aquaporin-8 / O94778*ENSMUSG0000003076223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR022357  Major intrinsic protein, conserved site
 IPR023271  Aquaporin-like
 IPR034294  Aquaporin transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0050891 multicellular organismal water homeostasis IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046930 pore complex IEA
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0015288 porin activity IEA


Pathways (from Reactome)
Pathway description
Vasopressin regulates renal water homeostasis via Aquaporins
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp5tm1Ask/Aqp5tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdc42tm1Fwa/Cdc42tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lgi4clp/Lgi4clp
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0004699 unilateral deafness "bilateral asymmetry in auditory function whereby one of the two ears displays auditory thresholds indicative of intact hearing while the other ear displays thresholds reflecting auditory dysfunction " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: B6.Cg-Aqp4tm1Ask

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006190 retinal ischemia "abnormal incidence of or response to loss of circulation in the retina; may be induced or spontaneous" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: B6.Cg-Aqp4tm1Ask

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011443 abnormal renal water transport "any anomaly in the directed movement of water (H2O) by the kidney" [GO:0003097]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011854 cerebral edema "excess accumulation of water in the intra- and/or extracellular spaces of the brain" [MGI:anna]
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Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Pdx1tm1Macd/Pdx1tm1Macd,Tg(tetO-Ipf1,lacZ)958.1Macd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024411 Aqp4 / aquaporin-4 isoform M1x / P55087* / aquaporin 4*  / complex






 

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