ENSMUSG00000044217


Mus musculus

Features
Gene ID: ENSMUSG00000044217
  
Biological name :Aqp5
  
Synonyms : Aqp5 / Aquaporin-5 / Q9WTY4
  
Possible biological names infered from orthology : P55064
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 99590782
Gene end: 99594829
  
Corresponding Affymetrix probe sets: 10426767 (MoGene1.0st)   1418818_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155623
Ensembl peptide - ENSMUSP00000085530
Ensembl peptide - ENSMUSP00000127611
Ensembl peptide - ENSMUSP00000155212
NCBI entrez gene - 11830     See in Manteia.
MGI - MGI:106215
RefSeq - NM_009701
RefSeq Peptide - NP_033831
swissprot - Q9WTY4
Ensembl - ENSMUSG00000044217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AQP5ENSGALG00000041878Gallus gallus
 AQP5ENSG00000161798Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp2 / P56402 / Aquaporin-2 / P41181*ENSMUSG0000002301364
Aqp6 / Q8C4A0 / Aquaporin-6 / Q13520*ENSMUSG0000004314452
Mip / P51180 / Lens fiber major intrinsic protein / P30301* / major intrinsic protein of lens fiber*ENSMUSG0000002538949
Aqp4 / aquaporin-4 isoform M1x / P55087* / aquaporin 4*ENSMUSG0000002441148
Aqp1 / Q02013 / Aquaporin-1 / P29972* / AC004691.2* / aquaporin 1 (Colton blood group)*ENSMUSG0000000465543
Aqp8 / P56404 / Aquaporin-8 / O94778*ENSMUSG0000003076226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR022357  Major intrinsic protein, conserved site
 IPR023271  Aquaporin-like
 IPR023276  Aquaporin 5
 IPR034294  Aquaporin transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006833 water transport TAS
 biological_processGO:0015670 carbon dioxide transport ISO
 biological_processGO:0030157 pancreatic juice secretion IEA
 biological_processGO:0034220 ion transmembrane transport IBA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0046541 saliva secretion IMP
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015250 water channel activity TAS
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Aqp5tm1Ask/Aqp5tm1Ask,Aqp8tm1Ask/Aqp8tm1Ask
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acetm7Keb/Acetm7Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005310 abnormal salivary gland physiology "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0012124 increased bronchoconstrictive response "enhanced or greater than expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [MGI:csmith]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0014026 abnormal respiratory epithelial transmembrane transport "any anomaly in the directed movement of a substance from one side of the respiratory epithelial cell membrane to the other" [MGI:csmith]
Show

Allelic Composition: Cacna1atg/Cacna1atg,Tg(Pcp2-TAg)4Horr/0
Genetic Background: B6J.Cg-Cacna1atg Tg(Pcp2-TAg)4Horr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000044217 Aqp5 / Q9WTY4 / Aquaporin-5 / P55064*  / complex






 

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