ENSG00000184588


Homo sapiens

Features
Gene ID: ENSG00000184588
  
Biological name :PDE4B
  
Synonyms : PDE4B / phosphodiesterase 4B / Q07343
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.3
Gene start: 65792514
Gene end: 66374579
  
Corresponding Affymetrix probe sets: 203708_at (Human Genome U133 Plus 2.0 Array)   211302_s_at (Human Genome U133 Plus 2.0 Array)   215671_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431909
Ensembl peptide - ENSP00000397548
Ensembl peptide - ENSP00000432400
Ensembl peptide - ENSP00000437249
Ensembl peptide - ENSP00000436104
Ensembl peptide - ENSP00000432592
Ensembl peptide - ENSP00000332116
Ensembl peptide - ENSP00000342637
Ensembl peptide - ENSP00000360084
Ensembl peptide - ENSP00000392947
NCBI entrez gene - 5142     See in Manteia.
OMIM - 600127
RefSeq - XM_017001446
RefSeq - NM_001037339
RefSeq - NM_001037340
RefSeq - NM_001037341
RefSeq - NM_001297440
RefSeq - NM_001297441
RefSeq - NM_001297442
RefSeq - NM_002600
RefSeq - XM_005270924
RefSeq - XM_005270925
RefSeq - XM_006710680
RefSeq - XM_011541566
RefSeq - XM_017001445
RefSeq Peptide - NP_001032416
RefSeq Peptide - NP_001032418
RefSeq Peptide - NP_001284369
RefSeq Peptide - NP_001284370
RefSeq Peptide - NP_001284371
RefSeq Peptide - NP_002591
RefSeq Peptide - NP_001032417
swissprot - Q07343
swissprot - X5DNX5
swissprot - E9PR34
swissprot - E9PNB0
swissprot - E9PMG3
swissprot - H0YCV7
swissprot - E9PJ03
Ensembl - ENSG00000184588
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4baENSDARG00000032868Danio rerio
 pde4bbENSDARG00000074233Danio rerio
 PDE4BENSGALG00000011094Gallus gallus
 Pde4bENSMUSG00000028525Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344870
PDE4A / P27815 / phosphodiesterase 4AENSG0000006598967
Q08493 / AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C ENSG0000028518859
PDE4C / Q08493 / phosphodiesterase 4CENSG0000010565059
PDE8A / O60658 / phosphodiesterase 8AENSG0000007341724
PDE1C / Q14123 / phosphodiesterase 1CENSG0000015467824
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323123
PDE1A / P54750 / phosphodiesterase 1AENSG0000011525222
PDE1B / Q01064 / phosphodiesterase 1BENSG0000012336021
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476221
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526819
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140818


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001780 neutrophil homeostasis ISS
 biological_processGO:0006198 cAMP catabolic process IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0030593 neutrophil chemotaxis ISS
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0035690 cellular response to drug ISS
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0050900 leukocyte migration ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide ISS
 biological_processGO:0071872 cellular response to epinephrine stimulus ISS
 biological_processGO:0086004 regulation of cardiac muscle cell contraction ISS
 biological_processGO:1901841 regulation of high voltage-gated calcium channel activity ISS
 biological_processGO:1901898 negative regulation of relaxation of cardiac muscle ISS
 cellular_componentGO:0000930 gamma-tubulin complex IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005891 voltage-gated calcium channel complex ISS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity ISS
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding IGI
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0044325 ion channel binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / reaction
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / reaction






 

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