ENSG00000105650


Homo sapiens

Features
Gene ID: ENSG00000105650
  
Biological name :PDE4C
  
Synonyms : PDE4C / phosphodiesterase 4C / Q08493
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.11
Gene start: 18208652
Gene end: 18248200
  
Corresponding Affymetrix probe sets: 206791_s_at (Human Genome U133 Plus 2.0 Array)   206792_x_at (Human Genome U133 Plus 2.0 Array)   211818_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474849
Ensembl peptide - ENSP00000474591
Ensembl peptide - ENSP00000476961
Ensembl peptide - ENSP00000262805
Ensembl peptide - ENSP00000402091
Ensembl peptide - ENSP00000439470
Ensembl peptide - ENSP00000469696
Ensembl peptide - ENSP00000470210
Ensembl peptide - ENSP00000472034
Ensembl peptide - ENSP00000473713
Ensembl peptide - ENSP00000473937
NCBI entrez gene - 5143     See in Manteia.
OMIM - 600128
RefSeq - XM_017026866
RefSeq - NM_000923
RefSeq - NM_001098818
RefSeq - NM_001098819
RefSeq - XM_011528056
RefSeq - XM_011528058
RefSeq Peptide - NP_001092288
RefSeq Peptide - NP_001092289
RefSeq Peptide - NP_001317101
RefSeq Peptide - NP_000914
swissprot - Q08493
swissprot - Q32MM7
swissprot - U3KPR3
swissprot - M0R1P5
swissprot - U3KPR4
swissprot - V9GYP2
swissprot - B7Z6T1
swissprot - O76104
Ensembl - ENSG00000105650
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4caENSDARG00000013221Danio rerio
 pde4cbENSDARG00000002411Danio rerio
 ENSGALG00000037029Gallus gallus
 Pde4cENSMUSG00000031842Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q08493 / AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C ENSG00000285188100
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344867
PDE4A / P27815 / phosphodiesterase 4AENSG0000006598967
PDE4B / Q07343 / phosphodiesterase 4BENSG0000018458861
PDE1C / Q14123 / phosphodiesterase 1CENSG0000015467824
PDE8A / O60658 / phosphodiesterase 8AENSG0000007341723
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323122
PDE1A / P54750 / phosphodiesterase 1AENSG0000011525222
PDE1B / Q01064 / phosphodiesterase 1BENSG0000012336022
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476221
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526820
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140818


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005929 cilium ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity TAS
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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