ENSG00000154678


Homo sapiens

Features
Gene ID: ENSG00000154678
  
Biological name :PDE1C
  
Synonyms : PDE1C / phosphodiesterase 1C / Q14123
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p14.3
Gene start: 31751179
Gene end: 32299329
  
Corresponding Affymetrix probe sets: 1554378_a_at (Human Genome U133 Plus 2.0 Array)   207303_at (Human Genome U133 Plus 2.0 Array)   216869_at (Human Genome U133 Plus 2.0 Array)   236344_at (Human Genome U133 Plus 2.0 Array)   239218_at (Human Genome U133 Plus 2.0 Array)   243564_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379494
Ensembl peptide - ENSP00000379492
Ensembl peptide - ENSP00000379496
Ensembl peptide - ENSP00000318105
Ensembl peptide - ENSP00000379485
Ensembl peptide - ENSP00000379487
NCBI entrez gene - 5137     See in Manteia.
OMIM - 602987
RefSeq - XM_017012267
RefSeq - NM_001191056
RefSeq - NM_001191057
RefSeq - NM_001191058
RefSeq - NM_001191059
RefSeq - NM_001322055
RefSeq - NM_001322056
RefSeq - NM_001322057
RefSeq - NM_001322058
RefSeq - NM_001322059
RefSeq - NM_005020
RefSeq - XM_017012264
RefSeq - XM_017012265
RefSeq - XM_017012266
RefSeq Peptide - NP_001177986
RefSeq Peptide - NP_001177987
RefSeq Peptide - NP_001177988
RefSeq Peptide - NP_001308984
RefSeq Peptide - NP_001308985
RefSeq Peptide - NP_001308986
RefSeq Peptide - NP_001308987
RefSeq Peptide - NP_001308988
RefSeq Peptide - NP_005011
RefSeq Peptide - NP_001177985
swissprot - A0A0A0MS69
swissprot - F8W905
swissprot - Q14123
Ensembl - ENSG00000154678
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01067973.1ENSDARG00000090398Danio rerio
 PDE1CENSGALG00000039935Gallus gallus
 Pde1cENSMUSG00000004347Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE1A / P54750 / phosphodiesterase 1AENSG0000011525247
PDE1B / Q01064 / phosphodiesterase 1BENSG0000012336041
PDE4A / P27815 / phosphodiesterase 4AENSG0000006598925
PDE4B / Q07343 / phosphodiesterase 4BENSG0000018458823
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344823
PDE4C / Q08493 / phosphodiesterase 4CENSG0000010565022
Q08493 / AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C ENSG0000028518822
PDE8A / O60658 / phosphodiesterase 8AENSG0000007341716
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323116
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140815
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526815
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476215


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013706  3"5"-cyclic nucleotide phosphodiesterase N-terminal
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007608 sensory perception of smell IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005929 cilium IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cam-PDE 1 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154678 PDE1C / Q14123 / phosphodiesterase 1C  / complex






 

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