ENSG00000073417


Homo sapiens

Features
Gene ID: ENSG00000073417
  
Biological name :PDE8A
  
Synonyms : O60658 / PDE8A / phosphodiesterase 8A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q25.3
Gene start: 84980440
Gene end: 85139145
  
Corresponding Affymetrix probe sets: 1552931_a_at (Human Genome U133 Plus 2.0 Array)   212521_s_at (Human Genome U133 Plus 2.0 Array)   212522_at (Human Genome U133 Plus 2.0 Array)   239874_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453808
Ensembl peptide - ENSP00000452907
Ensembl peptide - ENSP00000454094
Ensembl peptide - ENSP00000311453
Ensembl peptide - ENSP00000340679
Ensembl peptide - ENSP00000378056
Ensembl peptide - ENSP00000431976
Ensembl peptide - ENSP00000432309
NCBI entrez gene - 5151     See in Manteia.
OMIM - 602972
RefSeq - XM_017022311
RefSeq - NM_001243137
RefSeq - NM_002605
RefSeq - NM_173454
RefSeq - XM_011521668
RefSeq - XM_017022308
RefSeq - XM_017022309
RefSeq - XM_017022310
RefSeq Peptide - NP_775656
RefSeq Peptide - NP_001230066
RefSeq Peptide - NP_002596
swissprot - E9PIJ0
swissprot - O60658
swissprot - H0YNP3
swissprot - H0YKR1
Ensembl - ENSG00000073417
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde8aENSDARG00000087941Danio rerio
 PDE8AENSGALG00000005992Gallus gallus
 Pde8aENSMUSG00000025584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323165
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476263
PDE4A / P27815 / phosphodiesterase 4AENSG0000006598921
PDE4B / Q07343 / phosphodiesterase 4BENSG0000018458821
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344820
PDE4C / Q08493 / phosphodiesterase 4CENSG0000010565019
Q08493 / AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C ENSG0000028518819
PDE1B / Q01064 / phosphodiesterase 1BENSG0000012336015
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526815
PDE1C / Q14123 / phosphodiesterase 1CENSG0000015467815
PDE1A / P54750 / phosphodiesterase 1AENSG0000011525215
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013767  PAS fold
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR035965  PAS domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009187 cyclic nucleotide metabolic process NAS
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IMP
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity NAS
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity TAS
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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