ENSGALG00000005992


Gallus gallus

Features
Gene ID: ENSGALG00000005992
  
Biological name :PDE8A
  
Synonyms : PDE8A / phosphodiesterase 8A
  
Possible biological names infered from orthology : High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658 / O88502
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 10947158
Gene end: 11053735
  
Corresponding Affymetrix probe sets: Gga.11274.1.S1_s_at (Chicken Array)   GgaAffx.26688.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048225
NCBI entrez gene - 415455     See in Manteia.
RefSeq - XM_004943815
RefSeq - XM_004943816
RefSeq - XM_015292024
swissprot - A0A1D5P6A0
Ensembl - ENSGALG00000005992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde8aENSDARG00000087941Danio rerio
 PDE8AENSG00000073417Homo sapiens
 Pde8aENSMUSG00000025584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE8B* / O95263* / E9Q4S1* / AC022414.1* / phosphodiesterase 8B* / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B * / high affinity cAMP-specific and IBMX-...ENSGALG0000000433973
PDE4C* / Q08493* / Q3UEI1* / AC008397.2* / phosphodiesterase 4C* / cAMP-specific 3,5-cyclic phosphodiesterase 4C *ENSGALG0000003702919
PDE4D / phosphodiesterase 4D / Q01063* / Q08499* / cAMP-specific 3,5-cyclic phosphodiesterase 4D *ENSGALG0000001472719
PDE4B / cAMP-specific 3,5-cyclic phosphodiesterase 4B / Q07343* / phosphodiesterase 4B* / phosphodiesterase 4B, cAMP specific*ENSGALG0000001109417
PDE1C / phosphodiesterase 1C / Q14123* / Q64338*ENSGALG0000003993516
PDE7A / phosphodiesterase 7A / P70453* / Q13946* / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A *ENSGALG0000003839516
PDE1A / phosphodiesterase 1A / P54750* / phosphodiesterase 1A, calmodulin-dependent*ENSGALG0000000888516
PDE7B / phosphodiesterase 7B / Q9NP56* / Q9QXQ1* / cAMP-specific 3,5-cyclic phosphodiesterase 7B *ENSGALG0000001394115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013938  3"5"-cyclic nucleotide phosphodiesterase PDE8
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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