ENSGALG00000014727


Gallus gallus

Features
Gene ID: ENSGALG00000014727
  
Biological name :PDE4D
  
Synonyms : PDE4D / phosphodiesterase 4D
  
Possible biological names infered from orthology : cAMP-specific 3,5-cyclic phosphodiesterase 4D / Q01063 / Q08499
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 18254057
Gene end: 18507779
  
Corresponding Affymetrix probe sets: Gga.11223.1.S1_at (Chicken Array)   Gga.14192.1.S1_at (Chicken Array)   Gga.15137.1.S1_at (Chicken Array)   GgaAffx.11609.1.S1_at (Chicken Array)   GgaAffx.20270.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045799
Ensembl peptide - ENSGALP00000054616
Ensembl peptide - ENSGALP00000023705
NCBI entrez gene - 769469     See in Manteia.
RefSeq - XM_015277592
RefSeq - XM_004937258
RefSeq - XM_015277589
RefSeq - XM_015277590
RefSeq - XM_004937252
RefSeq - XM_004937253
RefSeq - XM_004937256
RefSeq - XM_004937257
swissprot - A0A1D5PP20
swissprot - F1NB56
swissprot - A0A1D5NZI1
Ensembl - ENSGALG00000014727
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4dENSDARG00000032761Danio rerio
 PDE4DENSG00000113448Homo sapiens
 Pde4dENSMUSG00000021699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE4C* / Q08493* / Q3UEI1* / AC008397.2* / phosphodiesterase 4C* / cAMP-specific 3,5-cyclic phosphodiesterase 4C *ENSGALG0000003702972
PDE4B / cAMP-specific 3,5-cyclic phosphodiesterase 4B / Q07343* / phosphodiesterase 4B* / phosphodiesterase 4B, cAMP specific*ENSGALG0000001109463
PDE1C / phosphodiesterase 1C / Q14123* / Q64338*ENSGALG0000003993525
PDE1A / phosphodiesterase 1A / P54750* / phosphodiesterase 1A, calmodulin-dependent*ENSGALG0000000888524
PDE8B* / O95263* / E9Q4S1* / AC022414.1* / phosphodiesterase 8B* / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B * / high affinity cAMP-specific and IBMX-...ENSGALG0000000433923
PDE8A / phosphodiesterase 8A / O60658* / O88502* / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A *ENSGALG0000000599221
PDE7A / phosphodiesterase 7A / P70453* / Q13946* / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A *ENSGALG0000003839520
PDE7B / phosphodiesterase 7B / Q9NP56* / Q9QXQ1* / cAMP-specific 3,5-cyclic phosphodiesterase 7B *ENSGALG0000001394120


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030814 obsolete regulation of cAMP metabolic process IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0032754 positive regulation of interleukin-5 production IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IEA
 biological_processGO:1901898 negative regulation of relaxation of cardiac muscle IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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