ENSMUSG00000021699


Mus musculus

Features
Gene ID: ENSMUSG00000021699
  
Biological name :Pde4d
  
Synonyms : cAMP-specific 3,5-cyclic phosphodiesterase 4D / Pde4d / Q01063
  
Possible biological names infered from orthology : phosphodiesterase 4D / Q08499
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D2.1
Gene start: 108449948
Gene end: 109953461
  
Corresponding Affymetrix probe sets: 10407097 (MoGene1.0st)   1435280_at (Mouse Genome 430 2.0 Array)   1459311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113024
Ensembl peptide - ENSMUSP00000136485
Ensembl peptide - ENSMUSP00000121592
Ensembl peptide - ENSMUSP00000119583
Ensembl peptide - ENSMUSP00000114945
Ensembl peptide - ENSMUSP00000114089
Ensembl peptide - ENSMUSP00000113610
Ensembl peptide - ENSMUSP00000113567
Ensembl peptide - ENSMUSP00000113488
Ensembl peptide - ENSMUSP00000073742
Ensembl peptide - ENSMUSP00000078891
Ensembl peptide - ENSMUSP00000112774
Ensembl peptide - ENSMUSP00000112991
NCBI entrez gene - 238871     See in Manteia.
MGI - MGI:99555
RefSeq - XM_006517649
RefSeq - NM_011056
RefSeq - XM_006517643
RefSeq - XM_006517644
RefSeq - XM_006517645
RefSeq - XM_006517646
RefSeq - XM_006517647
RefSeq - XM_006517648
RefSeq Peptide - NP_035186
swissprot - F7BK43
swissprot - B2KF84
swissprot - E9PVU7
swissprot - Q01063
swissprot - B2KF57
swissprot - B1PSD9
swissprot - A6XDB1
swissprot - A6XDB0
swissprot - A6XDA6
swissprot - A2RSH1
swissprot - F6YIS2
swissprot - F6QFD1
Ensembl - ENSMUSG00000021699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4dENSDARG00000032761Danio rerio
 PDE4DENSGALG00000014727Gallus gallus
 PDE4DENSG00000113448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde4b / phosphodiesterase 4B, cAMP specific / Q07343* / phosphodiesterase 4B*ENSMUSG0000002852568
Pde4a / O89084 / phosphodiesterase 4A, cAMP specific / P27815* / phosphodiesterase 4A*ENSMUSG0000003217764
Pde4c / Q3UEI1 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493* / AC008397.2* / phosphodiesterase 4C*ENSMUSG0000003184257
Pde1c / Q64338 / phosphodiesterase 1C / Q14123*ENSMUSG0000000434723
Pde8a / O88502 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658* / phosphodiesterase 8A*ENSMUSG0000002558421
Pde1a / phosphodiesterase 1A, calmodulin-dependent / P54750* / phosphodiesterase 1A*ENSMUSG0000005917321
Pde1b / Q01065 / Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Q01064* / phosphodiesterase 1B*ENSMUSG0000002248921
Pde7b / Q9QXQ1 / cAMP-specific 3,5-cyclic phosphodiesterase 7B / Q9NP56* / phosphodiesterase 7B*ENSMUSG0000001999020
Pde7a / P70453 / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A / Q13946* / phosphodiesterase 7A*ENSMUSG0000006909419
Pde8b / E9Q4S1 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B / O95263* / AC022414.1* / phosphodiesterase 8B* / high affinity cAMP-specific and IBMX-ins...ENSMUSG0000002168419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0006939 smooth muscle contraction IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007568 aging IMP
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0030814 obsolete regulation of cAMP metabolic process IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0032754 positive regulation of interleukin-5 production IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0045822 negative regulation of heart contraction IMP
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IMP
 biological_processGO:0061028 establishment of endothelial barrier ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071872 cellular response to epinephrine stimulus IMP
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IMP
 biological_processGO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IC
 biological_processGO:1901898 negative regulation of relaxation of cardiac muscle IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034704 calcium channel complex IDA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding IPI
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cnga2tm1Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Pde4btm1Mct/Pde4btm1Mct,Pde4dtm1Mct/Pde4d+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pde4btm1Mct/Pde4b+,Pde4dtm1Mct/Pde4dtm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Pde4dtm1Mct/Pde4dtm1Mct
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: Pde4dtm2Mct/Pde4dtm2Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pde4btm1Mct/Pde4btm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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