ENSMUSG00000021684


Mus musculus

Features
Gene ID: ENSMUSG00000021684
  
Biological name :Pde8b
  
Synonyms : E9Q4S1 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B / Pde8b
  
Possible biological names infered from orthology : AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 / O95263 / phosphodiesterase 8B
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 95024454
Gene end: 95250336
  
Corresponding Affymetrix probe sets: 10411171 (MoGene1.0st)   1435741_at (Mouse Genome 430 2.0 Array)   1437989_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070465
Ensembl peptide - ENSMUSP00000022192
Ensembl peptide - ENSMUSP00000124068
Ensembl peptide - ENSMUSP00000128987
Ensembl peptide - ENSMUSP00000125237
Ensembl peptide - ENSMUSP00000125191
Ensembl peptide - ENSMUSP00000125115
Ensembl peptide - ENSMUSP00000124704
Ensembl peptide - ENSMUSP00000124447
Ensembl peptide - ENSMUSP00000124409
NCBI entrez gene - 218461     See in Manteia.
MGI - MGI:2443999
RefSeq - XM_017315494
RefSeq - XM_006517588
RefSeq - XM_006517589
RefSeq - XM_006517590
RefSeq - XM_006517591
RefSeq - XM_006517592
RefSeq - XM_006517593
RefSeq - XM_006517594
RefSeq - XM_006517595
RefSeq - XM_011244649
RefSeq - XM_011244650
RefSeq - XM_011244651
RefSeq - XM_017315492
RefSeq - XM_017315493
RefSeq - NM_001170669
RefSeq - NM_172263
RefSeq - XM_006517585
RefSeq - XM_006517586
RefSeq - XM_006517587
RefSeq Peptide - NP_758467
RefSeq Peptide - NP_001164140
RefSeq Peptide - NP_001333711
swissprot - E9PYP0
swissprot - E9PXX4
swissprot - E9PX38
swissprot - E9Q8J6
swissprot - F7CT85
swissprot - E0CY70
swissprot - E0CXQ1
swissprot - E9PUL4
swissprot - E9Q7S6
swissprot - E9Q4S1
Ensembl - ENSMUSG00000021684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde8bENSDARG00000063706Danio rerio
 ENSGALG00000004339Gallus gallus
 AC022414.1ENSG00000284762Homo sapiens
 PDE8BENSG00000113231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde8a / O88502 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658* / phosphodiesterase 8A*ENSMUSG0000002558459
Pde4a / O89084 / phosphodiesterase 4A, cAMP specific / P27815* / phosphodiesterase 4A*ENSMUSG0000003217721
Pde4c / Q3UEI1 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493* / AC008397.2* / phosphodiesterase 4C*ENSMUSG0000003184219
Pde4b / phosphodiesterase 4B, cAMP specific / Q07343* / phosphodiesterase 4B*ENSMUSG0000002852519
Pde4d / Q01063 / cAMP-specific 3,5-cyclic phosphodiesterase 4D / Q08499* / phosphodiesterase 4D*ENSMUSG0000002169918
Pde7a / P70453 / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A / Q13946* / phosphodiesterase 7A*ENSMUSG0000006909415
Pde7b / Q9QXQ1 / cAMP-specific 3,5-cyclic phosphodiesterase 7B / Q9NP56* / phosphodiesterase 7B*ENSMUSG0000001999014
Pde1a / phosphodiesterase 1A, calmodulin-dependent / P54750* / phosphodiesterase 1A*ENSMUSG0000005917314
Pde1c / Q64338 / phosphodiesterase 1C / Q14123*ENSMUSG0000000434714
Pde1b / Q01065 / Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Q01064* / phosphodiesterase 1B*ENSMUSG0000002248914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR011006  CheY-like superfamily
 IPR013938  3"5"-cyclic nucleotide phosphodiesterase PDE8
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR035965  PAS domain superfamily
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0035106 operant conditioning IMP
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0090032 negative regulation of steroid hormone biosynthetic process IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IDA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002664 decreased circulating adrenocorticotropin level "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

Allelic Composition: Pde8atm1Dgen/Pde8atm1Dgen,Pde8btm1Dgen/Pde8btm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011549 increased urine corticosterone level "an increased amount of corticosterone in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Jak1M1Mhda/Jak1+
Genetic Background: C3HeB/FeJ-Jak1M1Mhda

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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