ENSMUSG00000028525


Mus musculus

Features
Gene ID: ENSMUSG00000028525
  
Biological name :Pde4b
  
Synonyms : Pde4b / phosphodiesterase 4B, cAMP specific
  
Possible biological names infered from orthology : phosphodiesterase 4B / Q07343
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 102087543
Gene end: 102607259
  
Corresponding Affymetrix probe sets: 10506335 (MoGene1.0st)   1422473_at (Mouse Genome 430 2.0 Array)   1422474_at (Mouse Genome 430 2.0 Array)   1442700_at (Mouse Genome 430 2.0 Array)   1444731_at (Mouse Genome 430 2.0 Array)   1446577_at (Mouse Genome 430 2.0 Array)   1447718_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102521
Ensembl peptide - ENSMUSP00000102524
Ensembl peptide - ENSMUSP00000134690
Ensembl peptide - ENSMUSP00000134340
Ensembl peptide - ENSMUSP00000133413
Ensembl peptide - ENSMUSP00000030251
Ensembl peptide - ENSMUSP00000095561
Ensembl peptide - ENSMUSP00000095562
Ensembl peptide - ENSMUSP00000102514
Ensembl peptide - ENSMUSP00000102517
Ensembl peptide - ENSMUSP00000102520
NCBI entrez gene - 18578     See in Manteia.
MGI - MGI:99557
RefSeq - NM_001177983
RefSeq - XM_017320030
RefSeq - XM_017320029
RefSeq - XM_006502857
RefSeq - XM_006502856
RefSeq - XM_006502855
RefSeq - NM_019840
RefSeq - NM_001177980
RefSeq - NM_001177981
RefSeq - NM_001177982
RefSeq Peptide - NP_001171452
RefSeq Peptide - NP_001171451
RefSeq Peptide - NP_001171453
RefSeq Peptide - NP_001171454
RefSeq Peptide - NP_062814
swissprot - B1AWC9
swissprot - B1AWD0
swissprot - Q3TTI9
swissprot - Q6IQY6
swissprot - Q80VK8
swissprot - Q8VBU5
swissprot - G3UZY9
swissprot - B1AWC8
swissprot - G3UZ46
swissprot - B1AWD1
swissprot - G3UWT3
Ensembl - ENSMUSG00000028525
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4baENSDARG00000032868Danio rerio
 pde4bbENSDARG00000074233Danio rerio
 PDE4BENSGALG00000011094Gallus gallus
 PDE4BENSG00000184588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde4d / Q01063 / cAMP-specific 3,5-cyclic phosphodiesterase 4D / Q08499* / phosphodiesterase 4D*ENSMUSG0000002169971
Pde4a / O89084 / phosphodiesterase 4A, cAMP specific / P27815* / phosphodiesterase 4A*ENSMUSG0000003217767
Pde4c / Q3UEI1 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493* / AC008397.2* / phosphodiesterase 4C*ENSMUSG0000003184257
Pde8a / O88502 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658* / phosphodiesterase 8A*ENSMUSG0000002558423
Pde1c / Q64338 / phosphodiesterase 1C / Q14123*ENSMUSG0000000434723
Pde1b / Q01065 / Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Q01064* / phosphodiesterase 1B*ENSMUSG0000002248922
Pde1a / phosphodiesterase 1A, calmodulin-dependent / P54750* / phosphodiesterase 1A*ENSMUSG0000005917322
Pde8b / E9Q4S1 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B / O95263* / AC022414.1* / phosphodiesterase 8B* / high affinity cAMP-specific and IBMX-ins...ENSMUSG0000002168421
Pde7b / Q9QXQ1 / cAMP-specific 3,5-cyclic phosphodiesterase 7B / Q9NP56* / phosphodiesterase 7B*ENSMUSG0000001999020
Pde7a / P70453 / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A / Q13946* / phosphodiesterase 7A*ENSMUSG0000006909419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001780 neutrophil homeostasis IMP
 biological_processGO:0006198 cAMP catabolic process ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0032743 positive regulation of interleukin-2 production ISO
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0050852 T cell receptor signaling pathway ISO
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071872 cellular response to epinephrine stimulus IMP
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IMP
 biological_processGO:1901841 regulation of high voltage-gated calcium channel activity IMP
 biological_processGO:1901898 negative regulation of relaxation of cardiac muscle IMP
 cellular_componentGO:0000930 gamma-tubulin complex IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IDA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030018 Z disc IMP
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0060076 excitatory synapse IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030552 cAMP binding ISO
 molecular_functionGO:0043015 gamma-tubulin binding IDA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DARPP-32 events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Viptm1Clw/Vip+
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Pde4btm1Mct/Pde4btm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde4btm1Mct/Pde4btm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pde4btm1Mct/Pde4btm1Mct,Pde4dtm1Mct/Pde4d+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pde4btm1Mct/Pde4b+,Pde4dtm1Mct/Pde4dtm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde4btm1Mct/Pde4btm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde4btm1Mct/Pde4btm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pde4btm1Mct/Pde4btm1Mct
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012314 enhanced learning "enhanced ability to aquire lasting change in behavior that is the result of experience" [http:psychology.about.com/od/lindex/g/learning.htm]
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Allelic Composition: Tbc1d32b2b3260.1Clo/Tbc1d32b2b3260.1Clo
Genetic Background: C57BL/6J-Tbc1d32b2b3260.1Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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