ENSMUSG00000022489


Mus musculus

Features
Gene ID: ENSMUSG00000022489
  
Biological name :Pde1b
  
Synonyms : Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Pde1b / Q01065
  
Possible biological names infered from orthology : phosphodiesterase 1B / Q01064
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 103503034
Gene end: 103530052
  
Corresponding Affymetrix probe sets: 10427369 (MoGene1.0st)   1449420_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023132
Ensembl peptide - ENSMUSP00000153722
Ensembl peptide - ENSMUSP00000153865
Ensembl peptide - ENSMUSP00000154483
NCBI entrez gene - 18574     See in Manteia.
MGI - MGI:97523
RefSeq - XM_006520588
RefSeq - NM_001285890
RefSeq - NM_008800
RefSeq Peptide - NP_032826
RefSeq Peptide - NP_001272819
swissprot - Q01065
swissprot - Q6PDS5
Ensembl - ENSMUSG00000022489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDE1BENSG00000123360Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pde1c / Q64338 / phosphodiesterase 1C / Q14123*ENSMUSG0000000434759
Pde1a / phosphodiesterase 1A, calmodulin-dependent / P54750* / phosphodiesterase 1A*ENSMUSG0000005917357
Pde4b / phosphodiesterase 4B, cAMP specific / Q07343* / phosphodiesterase 4B*ENSMUSG0000002852530
Pde4a / O89084 / phosphodiesterase 4A, cAMP specific / P27815* / phosphodiesterase 4A*ENSMUSG0000003217729
Pde4d / Q01063 / cAMP-specific 3,5-cyclic phosphodiesterase 4D / Q08499* / phosphodiesterase 4D*ENSMUSG0000002169929
Pde4c / Q3UEI1 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493* / AC008397.2* / phosphodiesterase 4C*ENSMUSG0000003184228
Pde8a / O88502 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A / O60658* / phosphodiesterase 8A*ENSMUSG0000002558422
Pde7a / P70453 / High affinity cAMP-specific 3,5-cyclic phosphodiesterase 7A / Q13946* / phosphodiesterase 7A*ENSMUSG0000006909421
Pde7b / Q9QXQ1 / cAMP-specific 3,5-cyclic phosphodiesterase 7B / Q9NP56* / phosphodiesterase 7B*ENSMUSG0000001999021
Pde8b / E9Q4S1 / High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B / O95263* / AC022414.1* / phosphodiesterase 8B* / high affinity cAMP-specific and IBMX-ins...ENSMUSG0000002168420


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013706  3"5"-cyclic nucleotide phosphodiesterase N-terminal
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels IMP
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IMP
 biological_processGO:0042428 serotonin metabolic process IMP
 biological_processGO:0046069 cGMP catabolic process IEA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004112 cyclic-nucleotide phosphodiesterase activity ISO
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity IEA
 molecular_functionGO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity ISO
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048101 calcium- and calmodulin-regulated 3",5"-cyclic-GMP phosphodiesterase activity ISO


Pathways (from Reactome)
Pathway description
Cam-PDE 1 activation
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Sp4tm1Krc/Sp4tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Sp4tm1Krc/Sp4tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Sp4tm1Krc/Sp4tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022489 Pde1b / Q01065 / Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B / Q01064* / phosphodiesterase 1B*  / complex






 

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