ENSG00000115252


Homo sapiens

Features
Gene ID: ENSG00000115252
  
Biological name :PDE1A
  
Synonyms : P54750 / PDE1A / phosphodiesterase 1A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q32.1
Gene start: 182140036
Gene end: 182523192
  
Corresponding Affymetrix probe sets: 1558680_s_at (Human Genome U133 Plus 2.0 Array)   208396_s_at (Human Genome U133 Plus 2.0 Array)   231213_at (Human Genome U133 Plus 2.0 Array)   233547_x_at (Human Genome U133 Plus 2.0 Array)   233549_at (Human Genome U133 Plus 2.0 Array)   236234_at (Human Genome U133 Plus 2.0 Array)   242789_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386767
Ensembl peptide - ENSP00000309269
Ensembl peptide - ENSP00000350858
Ensembl peptide - ENSP00000387037
Ensembl peptide - ENSP00000410309
NCBI entrez gene - 5136     See in Manteia.
OMIM - 171890
RefSeq - XM_017004302
RefSeq - NM_001003683
RefSeq - NM_001258312
RefSeq - NM_001258313
RefSeq - NM_001258314
RefSeq - NM_005019
RefSeq - XM_017004296
RefSeq - XM_017004297
RefSeq - XM_017004298
RefSeq - XM_017004299
RefSeq - XM_017004300
RefSeq - XM_017004301
RefSeq - XM_011511323
RefSeq - XM_011511324
RefSeq - XM_011511325
RefSeq - XM_011511326
RefSeq - XM_017004294
RefSeq - XM_017004295
RefSeq Peptide - NP_001245241
RefSeq Peptide - NP_001245242
RefSeq Peptide - NP_001245243
RefSeq Peptide - NP_005010
RefSeq Peptide - NP_001003683
swissprot - P54750
Ensembl - ENSG00000115252
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde1aENSDARG00000060875Danio rerio
 PDE1AENSGALG00000008885Gallus gallus
 Pde1aENSMUSG00000059173Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE1C / Q14123 / phosphodiesterase 1CENSG0000015467866
PDE1B / Q01064 / phosphodiesterase 1BENSG0000012336056
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344830
PDE4B / Q07343 / phosphodiesterase 4BENSG0000018458830
PDE4A / P27815 / phosphodiesterase 4AENSG0000006598930
PDE4C / Q08493 / phosphodiesterase 4CENSG0000010565029
Q08493 / AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C ENSG0000028518829
PDE8A / O60658 / phosphodiesterase 8AENSG0000007341723
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323122
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526821
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476221
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140820


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR013706  3"5"-cyclic nucleotide phosphodiesterase N-terminal
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0034391 regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0046069 cGMP catabolic process IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity TAS
 molecular_functionGO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047555 3",5"-cyclic-GMP phosphodiesterase activity TAS
 molecular_functionGO:0048101 calcium- and calmodulin-regulated 3",5"-cyclic-GMP phosphodiesterase activity IEA


Pathways (from Reactome)
Pathway description
Cam-PDE 1 activation
cGMP effects
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115252 PDE1A / P54750 / phosphodiesterase 1A  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr