ENSG00000285188


Homo sapiens

Features
Gene ID: ENSG00000285188
  
Biological name :AC008397.2
  
Synonyms : AC008397.2 / cAMP-specific 3,5-cyclic phosphodiesterase 4C / Q08493
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.11
Gene start: 18207961
Gene end: 18255419
  
Corresponding Affymetrix probe sets: 206791_s_at (Human Genome U133 Plus 2.0 Array)   206792_x_at (Human Genome U133 Plus 2.0 Array)   211818_s_at (Human Genome U133 Plus 2.0 Array)   231478_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000347689
NCBI entrez gene - 5143     See in Manteia.
swissprot - Q08493
Ensembl - ENSG00000285188
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pde4caENSDARG00000013221Danio rerio
 pde4cbENSDARG00000002411Danio rerio
 ENSGALG00000037029Gallus gallus
 Pde4cENSMUSG00000031842Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDE4C / Q08493 / phosphodiesterase 4CENSG00000105650100
PDE4D / Q08499 / phosphodiesterase 4DENSG0000011344867
PDE4A / P27815 / phosphodiesterase 4AENSG0000006598967
PDE4B / Q07343 / phosphodiesterase 4BENSG0000018458861
PDE1C / Q14123 / phosphodiesterase 1CENSG0000015467824
PDE8A / O60658 / phosphodiesterase 8AENSG0000007341723
PDE8B / O95263 / phosphodiesterase 8BENSG0000011323122
PDE1A / P54750 / phosphodiesterase 1AENSG0000011525222
PDE1B / Q01064 / phosphodiesterase 1BENSG0000012336022
AC022414.1 / high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B isoform 11 ENSG0000028476221
PDE7A / Q13946 / phosphodiesterase 7AENSG0000020526820
PDE7B / Q9NP56 / phosphodiesterase 7BENSG0000017140818


Protein motifs (from Interpro)
Interpro ID Name
 IPR002073  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain
 IPR003607  HD/PDEase domain
 IPR023088  3"5"-cyclic nucleotide phosphodiesterase
 IPR023174  3"5"-cyclic nucleotide phosphodiesterase, conserved site
 IPR036971  3"5"-cyclic nucleotide phosphodiesterase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006198 cAMP catabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005929 cilium ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004114 3",5"-cyclic-nucleotide phosphodiesterase activity IEA
 molecular_functionGO:0004115 3",5"-cyclic-AMP phosphodiesterase activity TAS
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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