ENSG00000183856


Homo sapiens

Features
Gene ID: ENSG00000183856
  
Biological name :IQGAP3
  
Synonyms : IQGAP3 / IQ motif containing GTPase activating protein 3 / Q86VI3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q22
Gene start: 156525405
Gene end: 156572604
  
Corresponding Affymetrix probe sets: 1569061_at (Human Genome U133 Plus 2.0 Array)   1569062_s_at (Human Genome U133 Plus 2.0 Array)   229538_s_at (Human Genome U133 Plus 2.0 Array)   241939_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354451
Ensembl peptide - ENSP00000436603
NCBI entrez gene - 128239     See in Manteia.
RefSeq - XM_017000318
RefSeq - NM_178229
RefSeq - XM_011509200
RefSeq - XM_011509201
RefSeq - XM_017000317
RefSeq - XM_011509198
RefSeq Peptide - NP_839943
swissprot - Q86VI3
swissprot - F2Z2E2
Ensembl - ENSG00000183856
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqgap3ENSDARG00000098650Danio rerio
 Iqgap3ENSMUSG00000028068Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1ENSG0000014057559
IQGAP2 / Q13576 / IQ motif containing GTPase activating protein 2ENSG0000014570350


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IPI
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0070856 myosin VI light chain binding IPI


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000183856 IQGAP3 / Q86VI3 / IQ motif containing GTPase activating protein 3  / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction






 

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