ENSGALG00000007820


Gallus gallus

Features
Gene ID: ENSGALG00000007820
  
Biological name :BTRC
  
Synonyms : beta-transducin repeat containing E3 ubiquitin protein ligase / BTRC
  
Possible biological names infered from orthology : F-box/WD repeat-containing protein 1A / Q3ULA2 / Q9Y297
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 22831879
Gene end: 22943782
  
Corresponding Affymetrix probe sets: GgaAffx.4891.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043680
Ensembl peptide - ENSGALP00000055865
Ensembl peptide - ENSGALP00000055071
Ensembl peptide - ENSGALP00000047372
Ensembl peptide - ENSGALP00000032557
NCBI entrez gene - 423854     See in Manteia.
RefSeq - XM_015288771
RefSeq - XM_015288766
RefSeq - XM_015288767
RefSeq - XM_015288768
RefSeq - XM_015288769
RefSeq - XM_015288770
RefSeq - XM_004942217
RefSeq - XM_004942220
RefSeq - XM_015288763
RefSeq - XM_015288764
RefSeq - XM_015288765
swissprot - A0A1D5PSH9
swissprot - A0A1D5PQA9
swissprot - A0A1D5P3W6
swissprot - F1NYG1
swissprot - A0A1D5NTM3
Ensembl - ENSGALG00000007820
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BTRCENSG00000166167Homo sapiens
 BtrcENSMUSG00000025217Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXW11 / F-box and WD repeat domain containing 11 / Q5SRY7* / Q9UKB1* / F-box/WD repeat-containing protein 11 *ENSGALG0000000222972
FBXW7 / F-box and WD repeat domain containing 7 / Q8VBV4* / Q969H0* / F-box/WD repeat-containing protein 7 *ENSGALG0000001010323
ENSGALG0000001733622
TRAF7 / TNF receptor associated factor 7 / Q6Q0C0*ENSGALG0000000576719
ZNF106 / zinc finger protein 106 / Q9H2Y7* / Zfp106*ENSGALG0000000908118
CDRT1* / Q5XX13* / FBXW10* / O95170* / Q5SUS0* / CMT1A duplicated region transcript 1* / F-box/WD repeat-containing protein 10 * / F-box and WD repeat domain containing 10*ENSGALG0000004456716
FBXW2 / F-box and WD repeat domain containing 2 / Q9UKT8*ENSGALG0000000086414
WDR86 / WD repeat domain 86 / Q86TI4*ENSGALG0000001969013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0042753 positive regulation of circadian rhythm IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0045309 protein phosphorylated amino acid binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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