ENSDARG00000029406


Danio rerio

Features
Gene ID: ENSDARG00000029406
  
Biological name :h2afx
  
Synonyms : h2afx / H2A histone family, member X / Q7ZUY3
  
Possible biological names infered from orthology : Histone H2AX / P16104 / P27661
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 30534702
Gene end: 30535327
  
Corresponding Affymetrix probe sets: Dr.17357.1.A1_at (Zebrafish Array)   NM_201073_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000040327
NCBI entrez gene - 394048     See in Manteia.
RefSeq - NM_201073
RefSeq Peptide - NP_957367
swissprot - Q7ZUY3
ZFIN ID - ZDB-GENE-040426-987
Ensembl - ENSDARG00000029406
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000026449Gallus gallus
 ENSGALG00000045705Gallus gallus
 H2AFXENSG00000188486Homo sapiens
 H2afxENSMUSG00000049932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010090688
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000008655288
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000009859588
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000008868688
hist1h2a11 / histone cluster 1 H2A family member 11 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010544488
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010301587
FP236812.4 / H2AFX* / P16104* / H2A histone family member X*ENSDARG0000011587587
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000009912387
CU457819.1 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000010027987
si:ch211-113a14.19 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000011348187
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010540087
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000011339987
CR354435.4 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000011370787
CR354435.3 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000011153687
si:ch1073-153i20.5 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000010547887
FP236812.2 / H2AFX* / P16104* / H2A histone family member X*ENSDARG0000010992687
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000005173687
FP340257.1 / H2AFX* / P27661* / P16104* / Histone H2AX * / H2A histone family member X*ENSDARG0000010002487
hist1h2a4 / histone cluster 1 H2A family member 4 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000010531487
hist1h2a2 / histone cluster 1 H2A family member 2 / H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*ENSDARG0000011164886


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005813 centrosome ISS
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr