ENSG00000100038


Homo sapiens

Features
Gene ID: ENSG00000100038
  
Biological name :TOP3B
  
Synonyms : DNA topoisomerase III beta / O95985 / TOP3B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.22
Gene start: 21957025
Gene end: 21982816
  
Corresponding Affymetrix probe sets: 213660_s_at (Human Genome U133 Plus 2.0 Array)   215781_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390824
Ensembl peptide - ENSP00000390209
Ensembl peptide - ENSP00000390977
Ensembl peptide - ENSP00000416451
Ensembl peptide - ENSP00000414538
Ensembl peptide - ENSP00000408282
Ensembl peptide - ENSP00000404600
Ensembl peptide - ENSP00000402622
Ensembl peptide - ENSP00000397221
Ensembl peptide - ENSP00000392480
Ensembl peptide - ENSP00000391857
Ensembl peptide - ENSP00000349705
Ensembl peptide - ENSP00000381773
Ensembl peptide - ENSP00000387554
NCBI entrez gene - 8940     See in Manteia.
OMIM - 603582
RefSeq - XM_017029041
RefSeq - NM_001282112
RefSeq - NM_001282113
RefSeq - NM_001349845
RefSeq - NM_003935
RefSeq - XM_005261811
RefSeq - XM_005261813
RefSeq - XM_006724349
RefSeq - XM_006724350
RefSeq - XM_011530482
RefSeq - XM_017029038
RefSeq - XM_017029039
RefSeq - XM_017029040
RefSeq Peptide - NP_003926
RefSeq Peptide - NP_001269041
RefSeq Peptide - NP_001269042
RefSeq Peptide - NP_001336774
RefSeq Peptide - NP_001336776
swissprot - H7C4B0
swissprot - C9JTQ7
swissprot - C9JT00
swissprot - C9JKE2
swissprot - C9JHR0
swissprot - C9JF56
swissprot - C9JEQ1
swissprot - C9JEI7
swissprot - C9J9X4
swissprot - O95985
swissprot - A0A024R1C2
swissprot - F2Z2A5
swissprot - H0Y6W0
Ensembl - ENSG00000100038
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top3bENSDARG00000027586Danio rerio
 TOP3BENSGALG00000030051Gallus gallus
 Top3bENSMUSG00000022779Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP3A / Q13472 / DNA topoisomerase III alphaENSG0000017730234


Protein motifs (from Interpro)
Interpro ID Name
 IPR000380  DNA topoisomerase, type IA
 IPR003601  DNA topoisomerase, type IA, domain 2
 IPR003602  DNA topoisomerase, type IA, DNA-binding domain
 IPR006171  TOPRIM domain
 IPR013497  DNA topoisomerase, type IA, central
 IPR013825  DNA topoisomerase, type IA, central region, subdomain 2
 IPR023405  DNA topoisomerase, type IA, core domain
 IPR023406  DNA topoisomerase, type IA, active site
 IPR034144  DNA topoisomerase 3-like, TOPRIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0007059 chromosome segregation IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005634 nucleus TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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