ENSMUSG00000022779


Mus musculus

Features
Gene ID: ENSMUSG00000022779
  
Biological name :Top3b
  
Synonyms : Q9Z321 / Top3b / topoisomerase (DNA) III beta
  
Possible biological names infered from orthology : DNA topoisomerase III beta / O95985
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 16870870
Gene end: 16892984
  
Corresponding Affymetrix probe sets: 10433910 (MoGene1.0st)   1438387_x_at (Mouse Genome 430 2.0 Array)   1448173_a_at (Mouse Genome 430 2.0 Array)   1456009_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023465
NCBI entrez gene - 21976     See in Manteia.
MGI - MGI:1333803
RefSeq - XM_017316937
RefSeq - NM_001326576
RefSeq - NM_011624
RefSeq - XM_006521992
RefSeq - XM_006521994
RefSeq - XM_006521995
RefSeq - XM_006521997
RefSeq - XM_006521991
RefSeq Peptide - NP_035754
RefSeq Peptide - NP_001313505
swissprot - Q3UJF5
swissprot - Q9Z321
Ensembl - ENSMUSG00000022779
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top3bENSDARG00000027586Danio rerio
 TOP3BENSGALG00000030051Gallus gallus
 TOP3BENSG00000100038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*ENSMUSG0000000281433


Protein motifs (from Interpro)
Interpro ID Name
 IPR000380  DNA topoisomerase, type IA
 IPR003601  DNA topoisomerase, type IA, domain 2
 IPR003602  DNA topoisomerase, type IA, DNA-binding domain
 IPR006171  TOPRIM domain
 IPR013497  DNA topoisomerase, type IA, central
 IPR013825  DNA topoisomerase, type IA, central region, subdomain 2
 IPR023405  DNA topoisomerase, type IA, core domain
 IPR023406  DNA topoisomerase, type IA, active site
 IPR034144  DNA topoisomerase 3-like, TOPRIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006265 DNA topological change IBA
 biological_processGO:0007059 chromosome segregation IMP
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IBA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Top3btm1Jcw/Top3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002742 enlarged submandibular lymph nodes "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0009631 enlarged axillary lymph nodes "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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