ENSMUSG00000020752


Mus musculus

Features
Gene ID: ENSMUSG00000020752
  
Biological name :Recql5
  
Synonyms : ATP-dependent DNA helicase Q5 / Q8VID5 / Recql5
  
Possible biological names infered from orthology : O94762 / RecQ like helicase 5
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 115892595
Gene end: 115933477
  
Corresponding Affymetrix probe sets: 10393021 (MoGene1.0st)   1421235_s_at (Mouse Genome 430 2.0 Array)   1441537_at (Mouse Genome 430 2.0 Array)   1457364_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021097
Ensembl peptide - ENSMUSP00000136178
Ensembl peptide - ENSMUSP00000136506
Ensembl peptide - ENSMUSP00000137157
NCBI entrez gene - 170472     See in Manteia.
MGI - MGI:2156841
RefSeq - XM_006532358
RefSeq - XM_006532359
RefSeq - XM_006532360
RefSeq - XM_006532361
RefSeq - NM_130454
RefSeq Peptide - NP_569721
swissprot - Q8VID5
swissprot - J3QP94
swissprot - J3QM90
swissprot - J3QMY1
Ensembl - ENSMUSG00000020752
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 recql5ENSDARG00000059556Danio rerio
 RECQL5ENSGALG00000002424Gallus gallus
 O94762ENSG00000108469Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*ENSMUSG0000003052824
Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*ENSMUSG0000003158321
Recql / Q9Z129 / RecQ protein-like / P46063* / RecQ like helicase*ENSMUSG0000003024317
Recql4 / RecQ like helicase 4ENSMUSG0000003376216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR004589  DNA helicase, ATP-dependent, RecQ type
 IPR010716  RecQ helicase-like 5
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032284  ATP-dependent DNA helicase RecQ, zinc-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006260 DNA replication ISO
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0035690 cellular response to drug IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051304 chromosome separation IEA
 biological_processGO:0072757 cellular response to camptothecin IMP
 biological_processGO:1990414 replication-born double-strand break repair via sister chromatid exchange IMP
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination IGI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016591 DNA-directed RNA polymerase II, holoenzyme IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0009378 four-way junction helicase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
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Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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