ENSMUSG00000022545


Mus musculus

Features
Gene ID: ENSMUSG00000022545
  
Biological name :Ercc4
  
Synonyms : DNA repair endonuclease XPF / Ercc4 / Q9QZD4
  
Possible biological names infered from orthology : ERCC excision repair 4, endonuclease catalytic subunit / Q92889
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 13109684
Gene end: 13150617
  
Corresponding Affymetrix probe sets: 10433620 (MoGene1.0st)   1432272_a_at (Mouse Genome 430 2.0 Array)   1440237_at (Mouse Genome 430 2.0 Array)   1441003_at (Mouse Genome 430 2.0 Array)   1448984_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114639
Ensembl peptide - ENSMUSP00000118553
Ensembl peptide - ENSMUSP00000023206
NCBI entrez gene - 50505     See in Manteia.
MGI - MGI:1354163
RefSeq - NM_015769
RefSeq Peptide - NP_056584
swissprot - Q9QZD4
swissprot - D6RHP2
swissprot - F7A043
Ensembl - ENSMUSG00000022545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ercc4ENSDARG00000014161Danio rerio
 ERCC4ENSGALG00000002981Gallus gallus
 ERCC4ENSG00000175595Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006166  ERCC4 domain
 IPR006167  DNA repair protein XPF
 IPR010994  RuvA domain 2-like
 IPR011335  Restriction endonuclease type II-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion IEA
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009650 UV protection IMP
 biological_processGO:0032205 negative regulation of telomere maintenance IEA
 biological_processGO:0033683 nucleotide-excision repair, DNA incision IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0061819 telomeric DNA-containing double minutes formation IEA
 biological_processGO:1901255 nucleotide-excision repair involved in interstrand cross-link repair IBA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IEA
 biological_processGO:1905765 negative regulation of protection from non-homologous end joining at telomere IEA
 biological_processGO:1905768 negative regulation of double-stranded telomeric DNA binding IEA
 cellular_componentGO:0000109 nucleotide-excision repair complex IEA
 cellular_componentGO:0000110 nucleotide-excision repair factor 1 complex IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005669 transcription factor TFIID complex IDA
 cellular_componentGO:0070522 ERCC4-ERCC1 complex IEA
 molecular_functionGO:0000014 single-stranded DNA endodeoxyribonuclease activity IBA
 molecular_functionGO:0001094 TFIID-class transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:1990599 3" overhang single-stranded DNA endodeoxyribonuclease activity IEA


Pathways (from Reactome)
Pathway description
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000026048 Ercc5 / ERCC excision repair 5, endonuclease / P28715*  / reaction / complex
 ENSMUSG00000003549 Ercc1 / P07903 / DNA excision repair protein ERCC-1 / P07992* / ERCC excision repair 1, endonuclease non-catalytic subunit*  / complex / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex






 

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