ENSMUSG00000026048


Mus musculus

Features
Gene ID: ENSMUSG00000026048
  
Biological name :Ercc5
  
Synonyms : Ercc5 / ERCC excision repair 5, endonuclease
  
Possible biological names infered from orthology : P28715
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.1
Gene start: 44147744
Gene end: 44181260
  
Corresponding Affymetrix probe sets: 10345981 (MoGene1.0st)   1450935_at (Mouse Genome 430 2.0 Array)   1457713_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027214
NCBI entrez gene - 22592     See in Manteia.
MGI - MGI:103582
RefSeq - XM_017319871
RefSeq - NM_011729
RefSeq - XM_006495890
RefSeq - XM_017319870
RefSeq Peptide - NP_035859
swissprot - E9QM61
Ensembl - ENSMUSG00000026048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ercc5ENSDARG00000023678Danio rerio
 ERCC5ENSGALG00000016860Gallus gallus
 ERCC5ENSG00000134899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001044  XPG/Rad2 endonuclease, eukaryotes
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR019974  XPG conserved site
 IPR029060  PIN-like domain superfamily
 IPR036279  5"-3" exonuclease, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009650 UV protection IEA
 biological_processGO:0010225 response to UV-C IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005662 DNA replication factor A complex IEA
 cellular_componentGO:0005675 holo TFIIH complex IEA
 cellular_componentGO:0016591 DNA-directed RNA polymerase II, holoenzyme IEA
 molecular_functionGO:0000405 bubble DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

 MP:0000478 delayed intestine development "slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oca2p-30PUb/Oca2p-x
Genetic Background: Not Specified

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oca2p-30PUb/Oca2p-x
Genetic Background: Not Specified

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-30PUb/Oca2p-x
Genetic Background: Not Specified

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005653 phototoxicity "condition caused by overexposure to UV light or from the combination of exposure to specific wavelengths and a phototoxic substance " [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:80519]
Show

Allelic Composition: Oca2p-30PUb/Oca2p-x
Genetic Background: Not Specified

Allelic Composition: Ercc5tm3Shm/Ercc5tm3Shm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ercc5tm4Shm/Ercc5tm4Shm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ercc5tm1Shm/Ercc5tm1Shm
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000003549 Ercc1 / P07903 / DNA excision repair protein ERCC-1 / P07992* / ERCC excision repair 1, endonuclease non-catalytic subunit*  / complex / reaction
 ENSMUSG00000022545 Ercc4 / Q9QZD4 / DNA repair endonuclease XPF / Q92889* / ERCC excision repair 4, endonuclease catalytic subunit*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex






 

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