Manteia

ENSMUSG00000019505

Mus musculus

Features

Gene ID:	ENSMUSG00000019505

Biological name :	Ubb

Synonyms :	P0CG49 / Ubb / ubiquitin B

Possible biological names infered from orthology :

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	B2
Gene start:	62551171
Gene end:	62553213

Corresponding Affymetrix probe sets:	10376864 (MoGene1.0st) 10414313 (MoGene1.0st) 1435643_x_at (Mouse Genome 430 2.0 Array) 1449436_s_at (Mouse Genome 430 2.0 Array) 1453723_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000019649 Ensembl peptide - ENSMUSP00000117361 NCBI entrez gene - 22187 See in Manteia. MGI - MGI:98888 RefSeq - NM_011664 RefSeq - NM_001313984 RefSeq Peptide - NP_001300913 RefSeq Peptide - NP_035794 swissprot - P0CG49 swissprot - Q5SX22 swissprot - Q78XY9 Ensembl - ENSMUSG00000019505

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
UBC	ENSGALG00000041277	Gallus gallus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ubc / P0CG50 / ubiquitin C / P0CG48*	ENSMUSG00000008348	99
Gm8797 / UBB* / P0CG47* / ubiquitin B*	ENSMUSG00000103034	25
Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*	ENSMUSG00000035692	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR000626	Ubiquitin domain
IPR019954	Ubiquitin conserved site
IPR019956	Ubiquitin
IPR029071	Ubiquitin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007141	male meiosis I	IMP
biological_process	GO:0007144	female meiosis I	IMP
biological_process	GO:0007623	circadian rhythm	TAS
biological_process	GO:0008584	male gonad development	IMP
biological_process	GO:0008585	female gonad development	IMP
biological_process	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development	IMP
biological_process	GO:0047497	mitochondrion transport along microtubule	ISO
biological_process	GO:0048812	neuron projection morphogenesis	ISO
biological_process	GO:0051881	regulation of mitochondrial membrane potential	ISO
biological_process	GO:0060612	adipose tissue development	IMP
biological_process	GO:0060613	fat pad development	IMP
biological_process	GO:0061136	regulation of proteasomal protein catabolic process	ISO
biological_process	GO:0072520	seminiferous tubule development	IMP
biological_process	GO:0097009	energy homeostasis	IMP
biological_process	GO:1901214	regulation of neuron death	ISO
biological_process	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	ISO
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0043005	neuron projection	ISO
cellular_component	GO:0043025	neuronal cell body	ISO
cellular_component	GO:0043209	myelin sheath	IDA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000837	abnormal hypothalamus morphology	"any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001125	abnormal oocytes	"anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001928	abnormal ovulation	"aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0001929	abnormal gametogenesis	"defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0002680	decreased number of corpora lutea	"fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0002682	reduced number of mature ovarian follicles	"fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0003205	testicular atrophy	"wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0003212	susceptibility to age related obesity	"increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0003224	neuron degeneration	"a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0004856	decreased ovary weight	"reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0004901	decreased male germ cell number	"reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0005168	abnormal female meiosis	"malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0005431	oocyte depletion	"reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0005448	abnormal energy balance	"aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0008261	arrest of male meiosis	"cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0009363	abnormal secondary ovarian follicle morphology	"any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0009375	thin zona pellucida	"reduced thickness of the solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0011957	decreased compensatory feeding amount	"decreased amount of food consumed after a period of fasting" [MGI:csmith]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl
MP:0013600	testis degeneration	"a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]	Show Allelic Composition: Ednrb^s/Ednrb^s-13Pub Genetic Background: involves: 101/Rl * C3H/Rl

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr