ENSMUSG00000025383


Mus musculus

Features
Gene ID: ENSMUSG00000025383
  
Biological name :Il23a
  
Synonyms : Il23a / Interleukin-23 subunit alpha / Q9EQ14
  
Possible biological names infered from orthology : Q9NPF7
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128296139
Gene end: 128298752
  
Corresponding Affymetrix probe sets: 10373358 (MoGene1.0st)   1419529_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026449
NCBI entrez gene - 83430     See in Manteia.
MGI - MGI:1932410
RefSeq - NM_031252
RefSeq Peptide - NP_112542
swissprot - Q9EQ14
Ensembl - ENSMUSG00000025383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL23AENSG00000110944Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR010831  Interleukin-23 alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity IEA
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IEA
 biological_processGO:0042098 T cell proliferation IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043382 positive regulation of memory T cell differentiation IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0051135 positive regulation of NK T cell activation IEA
 biological_processGO:0051142 positive regulation of NK T cell proliferation IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IDA
 biological_processGO:2000318 positive regulation of T-helper 17 type immune response IDA
 biological_processGO:2000330 positive regulation of T-helper 17 cell lineage commitment IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0070743 interleukin-23 complex IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045519 interleukin-23 receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-23 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0001830 decreased activated T cell number "reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il12btm2Lky/Il12btm2Lky
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S4/SvJae * BALB/c * C57BL/6J)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kltm1Lex/Kltm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il12btm2Lky/Il12btm2Lky
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S4/SvJae * BALB/c * C57BL/6J)

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il12btm2Lky/Il12btm2Lky
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S4/SvJae * BALB/c * C57BL/6J)

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Apctm1Tno/Apc+,Tg(CDX2-cre/ERT)#Erf/0
Genetic Background: involves: 129S4/SvJae

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: C57BL/6-Il23atm1.1Thak

Allelic Composition: Il12atm1Cab/Il12atm1Cab,Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: B6.Cg-Il12atm1Cab Il23atm1.1Thak

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

 MP:0008051 abnormal memory T cell physiology "any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: PfasSofa-2J/Pfas+
Genetic Background: B6(Cg)-PfasSofa-2J/GrsrJ

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Il23atm1Gdy/Il23a+
Genetic Background: B6.Cg-Il23atm1Gdy

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: C57BL/6-Il23atm1.1Thak

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il23atm1.1Thak/Il23atm1.1Thak
Genetic Background: C57BL/6-Il23atm1.1Thak

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: Not Specified

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Jag2tm1Grid/Jag2+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il23atm1Ngh/Il23atm1Ngh
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: Not Specified

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sfrp2tm1Ktas/Sfrp2tm1Ktas
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / reaction / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000049093 Il23r / interleukin 23 receptor / Q5VWK5*  / complex






 

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