ENSG00000110944


Homo sapiens

Features
Gene ID: ENSG00000110944
  
Biological name :IL23A
  
Synonyms : IL23A / interleukin 23 subunit alpha / Q9NPF7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.3
Gene start: 56334174
Gene end: 56340410
  
Corresponding Affymetrix probe sets: 220054_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000228534
NCBI entrez gene - 51561     See in Manteia.
OMIM - 605580
RefSeq - NM_016584
RefSeq - XM_011538477
RefSeq Peptide - NP_057668
swissprot - Q9NPF7
Ensembl - ENSG00000110944
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il23aENSMUSG00000025383Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR010831  Interleukin-23 alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032693 negative regulation of interleukin-10 production IMP
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production TAS
 biological_processGO:0032733 positive regulation of interleukin-10 production TAS
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0032740 positive regulation of interleukin-17 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032816 positive regulation of natural killer cell activation IC
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IDA
 biological_processGO:0034105 positive regulation of tissue remodeling IC
 biological_processGO:0038155 interleukin-23-mediated signaling pathway TAS
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IDA
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043382 positive regulation of memory T cell differentiation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0050729 positive regulation of inflammatory response IC
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0051135 positive regulation of NK T cell activation IDA
 biological_processGO:0051142 positive regulation of NK T cell proliferation IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:2000318 positive regulation of T-helper 17 type immune response IEA
 biological_processGO:2000330 positive regulation of T-helper 17 cell lineage commitment IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0070743 interleukin-23 complex IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045519 interleukin-23 receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Interleukin-23 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000096996 P42701 / IL12RB1 / interleukin 12 receptor subunit beta 1  / complex
 ENSG00000113302 IL12B / P29460 / interleukin 12B  / reaction / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex
 ENSG00000162594 IL23R / Q5VWK5 / interleukin 23 receptor  / complex
 ENSG00000138378 STAT4 / Q14765 / signal transducer and activator of transcription 4  / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex






 

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