ENSMUSG00000020151


Mus musculus

Features
Gene ID: ENSMUSG00000020151
  
Biological name :Ptprr
  
Synonyms : protein tyrosine phosphatase, receptor type, R / Ptprr / Q62132
  
Possible biological names infered from orthology : Q15256
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 116018213
Gene end: 116274932
  
Corresponding Affymetrix probe sets: 10366457 (MoGene1.0st)   1426047_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120965
Ensembl peptide - ENSMUSP00000100907
Ensembl peptide - ENSMUSP00000114455
Ensembl peptide - ENSMUSP00000064392
Ensembl peptide - ENSMUSP00000122259
NCBI entrez gene - 19279     See in Manteia.
MGI - MGI:109559
RefSeq - XM_006513383
RefSeq - NM_001161837
RefSeq - NM_001161838
RefSeq - NM_001161839
RefSeq - NM_001161840
RefSeq - NM_001358484
RefSeq - NM_011217
RefSeq - XM_006513382
RefSeq Peptide - NP_001155311
RefSeq Peptide - NP_001155312
RefSeq Peptide - NP_001345413
RefSeq Peptide - NP_035347
RefSeq Peptide - NP_001155309
RefSeq Peptide - NP_001155310
swissprot - Q5U1U6
swissprot - Q62132
Ensembl - ENSMUSG00000020151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprrENSDARG00000105744Danio rerio
 ENSGALG00000040855Gallus gallus
 ENSGALG00000010148Gallus gallus
 PTPRRENSG00000153233Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpn5 / P54830 / Tyrosine-protein phosphatase non-receptor type 5 / P54829* / protein tyrosine phosphatase, non-receptor type 5*ENSMUSG0000003085436
Ptpn7 / Q8BUM3 / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA. / P35236* / protein tyrosine phosphatase, non-receptor type 7*ENSMUSG0000003150629
Ptprn / protein tyrosine phosphatase, receptor type, N / Q16849*ENSMUSG0000002620421
P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*ENSMUSG0000004373320
P80560 / Ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / Q92932* / protein tyrosine phosphatase, receptor type N2*ENSMUSG0000005655319
Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*ENSMUSG0000000426618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008356  Protein-tyrosine phosphatase, KIM-containing
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016334  Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development ISS
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0010633 negative regulation of epithelial cell migration ISO
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0038128 ERBB2 signaling pathway ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Casp1tm1Flv/Casp1tm1Flv,Casp4del/Casp4del
Genetic Background: B6.129S2-Casp1tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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