ENSMUSG00000030854


Mus musculus

Features
Gene ID: ENSMUSG00000030854
  
Biological name :Ptpn5
  
Synonyms : P54830 / Ptpn5 / Tyrosine-protein phosphatase non-receptor type 5
  
Possible biological names infered from orthology : P54829 / protein tyrosine phosphatase, non-receptor type 5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 47077795
Gene end: 47133684
  
Corresponding Affymetrix probe sets: 10563685 (MoGene1.0st)   1423544_at (Mouse Genome 430 2.0 Array)   1425130_a_at (Mouse Genome 430 2.0 Array)   1425131_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033142
Ensembl peptide - ENSMUSP00000099686
NCBI entrez gene - 19259     See in Manteia.
MGI - MGI:97807
RefSeq - XM_017322046
RefSeq - NM_001163565
RefSeq - NM_013643
RefSeq - XM_006540713
RefSeq - XM_006540714
RefSeq - XM_006540715
RefSeq Peptide - NP_038671
RefSeq Peptide - NP_001157037
swissprot - P54830
Ensembl - ENSMUSG00000030854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn5ENSDARG00000074866Danio rerio
 PTPN5ENSGALG00000006368Gallus gallus
 PTPN5ENSG00000110786Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprr / Q62132 / protein tyrosine phosphatase, receptor type, R / Q15256*ENSMUSG0000002015143
Ptpn7 / Q8BUM3 / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA. / P35236* / protein tyrosine phosphatase, non-receptor type 7*ENSMUSG0000003150632
P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*ENSMUSG0000004373324
Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*ENSMUSG0000000426623
Ptprn / protein tyrosine phosphatase, receptor type, N / Q16849*ENSMUSG0000002620422
P80560 / Ptprn2 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / Q92932* / protein tyrosine phosphatase, receptor type N2*ENSMUSG0000005655322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008356  Protein-tyrosine phosphatase, KIM-containing
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016334  Protein-tyrosine phosphatase, receptor type R/non-receptor type 5
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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