ENSMUSG00000056553


Mus musculus

Features
Gene ID: ENSMUSG00000056553
  
Biological name :Ptprn2
  
Synonyms : P80560 / protein tyrosine phosphatase, receptor type, N polypeptide 2 / Ptprn2
  
Possible biological names infered from orthology : protein tyrosine phosphatase, receptor type N2 / Q92932
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F2
Gene start: 116485720
Gene end: 117276849
  
Corresponding Affymetrix probe sets: 10399121 (MoGene1.0st)   1425724_at (Mouse Genome 430 2.0 Array)   1435968_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064046
Ensembl peptide - ENSMUSP00000139978
NCBI entrez gene - 19276     See in Manteia.
MGI - MGI:107418
RefSeq - XM_011244019
RefSeq - NM_011215
RefSeq Peptide - NP_035345
swissprot - P80560
swissprot - Q3UU93
Ensembl - ENSMUSG00000056553
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprn2ENSDARG00000035970Danio rerio
 PTPRN2ENSGALG00000030054Gallus gallus
 PTPRN2ENSG00000155093Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprn / protein tyrosine phosphatase, receptor type, N / Q16849*ENSMUSG0000002620442
P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*ENSMUSG0000004373314
Ptprr / Q62132 / protein tyrosine phosphatase, receptor type, R / Q15256*ENSMUSG0000002015113
Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*ENSMUSG0000000426613
Ptpn5 / P54830 / Tyrosine-protein phosphatase non-receptor type 5 / P54829* / protein tyrosine phosphatase, non-receptor type 5*ENSMUSG0000003085412
Ptpn7 / Q8BUM3 / Mus musculus protein tyrosine phosphatase, non-receptor type 7 (Ptpn7), transcript variant 2, mRNA. / P35236* / protein tyrosine phosphatase, non-receptor type 7*ENSMUSG0000003150610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR021613  Protein-tyrosine phosphatase receptor IA-2 ectodomain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029403  RESP18 domain
 IPR033522  Receptor-type tyrosine-protein phosphatase-like N/N2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007269 neurotransmitter secretion IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035773 insulin secretion involved in cellular response to glucose stimulus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IDA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Daxxtm1Maul/Daxxtm1Maul
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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