ENSMUSG00000052013


Mus musculus

Features
Gene ID: ENSMUSG00000052013
  
Biological name :Btla
  
Synonyms : B and T lymphocyte associated / Btla
  
Possible biological names infered from orthology : Q7Z6A9
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B5
Gene start: 45224315
Gene end: 45252895
  
Corresponding Affymetrix probe sets: 10435982 (MoGene1.0st)   1455656_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099866
Ensembl peptide - ENSMUSP00000067877
NCBI entrez gene - 208154     See in Manteia.
MGI - MGI:2658978
RefSeq - XM_006521908
RefSeq - NM_001037719
RefSeq - NM_177584
RefSeq - XM_006521907
RefSeq Peptide - NP_001032808
RefSeq Peptide - NP_808252
swissprot - E9QNY6
swissprot - A0A0R4J1A0
Ensembl - ENSMUSG00000052013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX897691.1ENSDARG00000105033Danio rerio
 BTLAENSG00000186265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Costimulation by the CD28 family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Btlatm1Kmm/Btlatm1Kmm
Genetic Background: B6.129S-Btlatm1Kmm

Allelic Composition: Btlatm1Dgra/Btlatm1Dgra
Genetic Background: involves: C57BL/6

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm
Genetic Background: B6.129S-Btlatm1Kmm

 MP:0004752 decreased length of allograft survival "compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: B6.129S-Pdcd1tm1Hon Btlatm1Kmm

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm
Genetic Background: B6.129S-Btlatm1Kmm

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Btlatm1Kmm/Btlatm1Kmm
Genetic Background: B6.129S-Btlatm1Kmm

Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: B6.129S-Pdcd1tm1Hon Btlatm1Kmm

Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S/SvEv * BALB/c * C3H * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-1tm1Siz/Nkx3-1tm1Siz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm
Genetic Background: B6.129S-Btlatm1Kmm

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Btlatm1Kmm/Btlatm1Kmm
Genetic Background: B6.129S-Btlatm1Kmm

 MP:0008749 abnormal peripheral T cell anergy "any anomaly of the processes of T cell anergy that occur outside the thymus" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Btlatm1Dgra/Btlatm1Dgra
Genetic Background: involves: C57BL/6

Allelic Composition: Btlatm1Dgra/Btlatm1Dgra,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6

Allelic Composition: Btlatm1Dgra/Btlatm1Dgra,Tg(TcraTcrb)1100Mjb/?
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex






 

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