ENSMUSG00000073414


Mus musculus

Features
Gene ID: ENSMUSG00000073414
  
Biological name :Mpig6b
  
Synonyms : D7PDD4 / Megakaryocyte and platelet inhibitory receptor G6b / Mpig6b
  
Possible biological names infered from orthology : O95866
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35062693
Gene end: 35066184
  
Corresponding Affymetrix probe sets: 10450412 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000133377
Ensembl peptide - ENSMUSP00000094950
NCBI entrez gene - 106722     See in Manteia.
MGI - MGI:2146995
RefSeq - XM_011246241
RefSeq - NM_001033221
RefSeq - NM_001191012
RefSeq - XM_006523419
RefSeq Peptide - NP_001028393
RefSeq Peptide - NP_001177941
swissprot - D7PDD4
swissprot - D3YVS6
Ensembl - ENSMUSG00000073414
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MPIG6BENSG00000204420Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR028070  G6B family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030219 megakaryocyte differentiation IEA
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0035855 megakaryocyte development IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mpig6btm1.1Arte/Mpig6btm1.1Arte,Gp6tm1Ware/Gp6tm1Ware
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009448 decreased platelet ATP level "reduced concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011746 spleen fibrosis "invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury" [MGI:csmith]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011747 myelofibrosis "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tg(CAG-Lyn*)#Paau/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex






 

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