Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0000238	deficiency of pre-B cells	"lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: P2rx2^tm1Ckn/P2rx2^tm1Ckn,P2rx3^tm1Ckn/P2rx3^tm1Ckn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^m1Anu/Cd79a^m1Anu Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd Allelic Composition: Cd79a^m1Anu/Cd79a^m1Anu Genetic Background: C57BL/6-Cd79a^m1Anu Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129P2/OlaHsd
MP:0000321	increased bone marrow cell number	"increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Atxn1l^tm2.1Hzo/Atxn1l⁺ Genetic Background: B6.129S7-Atxn1l^tm2.1Hzo
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Bid^tm1.1Ast/Bid^tm1.1Ast Genetic Background: involves: BALB/cJ * C57BL/6 * NZB
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Bid^tm1.1Ast/Bid^tm1.1Ast Genetic Background: involves: BALB/cJ * C57BL/6 * NZB
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Trp53^tm1Brn/Trp53^tm1Brn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺,Tg(BCL2)22Wehi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Ssb^tm1Rjma/Ssb^tm2.1Rjma,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S/SvEv * BALB/c
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺,Tg(BCL2)22Wehi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0000716	abnormal immune system cell morphology	"anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scnn1a^tm1Hum/Scnn1a^tm1Hum Genetic Background: involves: 129/Sv
MP:0000717	abnormal lymphocyte number	"deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001800	abnormal humoral immune response	"abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^m1Btlr/Cd79a^m1Btlr Genetic Background: involves: C57BL/6J * C57BL/10J Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj
MP:0001802	arrested B cell development	"inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm5Cgn/Cd79a^tm5.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn,Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Cd79a^{tm2(cre/Esr1)Reth}/Cd79a⁺,Rag1^tm1.1Sadu/Rag1^tm1.1Sadu Genetic Background:* involves: BALB/c Allelic Composition: Hdac1^tm1.1Pmt/Hdac1^tm1.1Pmt,Hdac2^tm1.1Pmt/Hdac2^tm1.1Pmt,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N Allelic Composition: Gt(ROSA)26Sor^{tm2(CAG-Notch2)Uzs}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6J Allelic Composition: Ebf1^tm1.1Rug/Ebf1^tm1.1Rug,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * SJL Allelic Composition: Ssb^tm1Rjma/Ssb^tm2.1Rjma,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S/SvEv * BALB/c Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Cd79a^m1Anu/Cd79a^m1Anu Genetic Background: involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd Allelic Composition: Cd79a^m1Btlr/Cd79a^m1Btlr Genetic Background: involves: C57BL/6J * C57BL/10J Allelic Composition: Ssb^tm1Rjma/Ssb^tm2.1Rjma,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S/SvEv * BALB/c
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^m1Btlr/Cd79a^m1Btlr Genetic Background: involves: C57BL/6J * C57BL/10J Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Ssb^tm1Rjma/Ssb^tm2.1Rjma,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S/SvEv * BALB/c Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J Allelic Composition: Cd79a^m2Btlr/Cd79a^m2Btlr Genetic Background: C57BL/6J-Cd79a^m2Btlr
MP:0001807	decreased IgA	"less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: P2rx2^tm1Ckn/P2rx2^tm1Ckn,P2rx3^tm1Ckn/P2rx3^tm1Ckn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm4.1Cgn/Cd79a^tm4.1Cgn Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dnmt1^tm2Jae/Dnmt1^tm2Jae,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: P2rx2^tm1Ckn/P2rx2^tm1Ckn,P2rx3^tm1Ckn/P2rx3^tm1Ckn Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnmt1^tm2Jae/Dnmt1^tm2Jae,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Cd79a^{tm1(BAP31N-EGFP)Pld}/Cd79a^{tm1(BAP31N-EGFP)Pld} Genetic Background: Not Specified
MP:0002356	abnormal spleen red pulp morphology	"anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Ins2^tm1Jja/Ins2^tm1Jja Genetic Background: NOD.129S2-Ins2^tm1Jja
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak
MP:0002440	abnormal memory B cell morphology/development	"anomalous structure, differentiation, or number of cells of the B lymphocyte lineage that do not secrete antibody after an intitial contact with antigen, but can be rapidly activated after a second challenge with the same antigen" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl
MP:0002458	abnormal B cell number	"deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Nfatc2^tm1Rao/Nfatc2^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺,Tg(BCL2)22Wehi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi Allelic Composition: Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J
MP:0002460	decreased circulating immunoglobulin concentration	"less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pycard^tm1Flv/Pycard^tm1Flv Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002491	decreased IgD	"less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002492	decreased IgE	"less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Traf3ip2^tm1Sbn/Traf3ip2^tm1Sbn Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
MP:0002827	abnormal renal corpuscle	"anomalous structure or development of either Bowman s capsules and/or the glomeruli contained therein" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003132	increased number of pre-B cells	"greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0003643	spleen atrophy	"wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6
MP:0004046	abnormal mitosis	"anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J
MP:0004771	increased anti-single stranded DNA antibody level	"increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0004801	increased susceptibility to systemic lupus erythematosus	"greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J
MP:0004815	abnormal somatic hypermutation frequency	"any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl
MP:0004816	abnormal class switch recombination	"anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Cd79a^m1Btlr/Cd79a^m1Btlr Genetic Background: involves: C57BL/6J Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ctnnbl1^tm1.1Crad/Ctnnbl1^tm1.1Crad Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0004829	increased anti-chromatin antibody level	"increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6
MP:0004939	abnormal B cell morphology	"any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dynll1^tm1.1Jhh/Dynll1^tm1.1Jhh Genetic Background: B6.Cg-Dynll1^tm1.1Jhh Cd79a^tm1(Cre)Reth
MP:0004940	abnormal B-1 B cell morphology	"any structural anomaly in the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]	Show Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Ssb^tm1Rjma/Ssb^tm2.1Rjma,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S/SvEv * BALB/c
MP:0004973	increased regulatory T cell number	"greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0004978	decreased B-1 B cell number	"reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^m2Btlr/Cd79a^m2Btlr Genetic Background: C57BL/6J-Cd79a^m2Btlr
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(CAG-Notch2)Uzs}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6J
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm4Cgn/Cd79a^tm4.1Cgn,Tg(Cr2-cre)3Cgn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm5Cgn/Cd79a^tm5.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Cd79a^tm5Cgn/Cd79a^tm5.1Cgn,Tg(Cr2-cre)3Cgn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn Genetic Background: involves: C57BL/6 * C.B-20 Allelic Composition: Srsf3^tm1Pjln/Srsf3^tm1Pjln,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm3Cgn/Cd79a^tm3Cgn,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1.1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk,Tg(IghelMD4)4Ccg/0,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dicer1^tm1Mmk/Dicer1^tm1Mmk,Tg(BCL2)22Wehi/0 Genetic Background: involves: BALB/c * C57BL/6JWehi * SJL/JWehi Allelic Composition: Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Dicer1^tm1Mmk/Dicer1^tm1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c Allelic Composition: Hdac1^tm1.1Pmt/Hdac1^tm1.1Pmt,Hdac2^tm1.1Pmt/Hdac2^tm1.1Pmt,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Cd79a^m1Btlr/Cd79a^m1Btlr Genetic Background: involves: C57BL/6J * C57BL/10J Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB Allelic Composition: Gt(ROSA)26Sor^{tm2(CAG-Notch2)Uzs}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6J Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1.1Cgn/Cd79a⁺,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Trp53^tm1Brn/Trp53^tm1Brn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Ssb^tm1Rjma/Ssb^tm2.1Rjma,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S/SvEv * BALB/c Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: P2rx2^tm1Ckn/P2rx2^tm1Ckn,P2rx3^tm1Ckn/P2rx3^tm1Ckn Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005093	impaired B cell proliferation	"absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ctnnbl1^tm1.1Crad/Ctnnbl1^tm1.1Crad Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0005153	abnormal B cell proliferation	"change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ctnnbl1^tm1.1Crad/Ctnnbl1^tm1.1Crad Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0005154	increased B cell proliferation	"greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Kdr^tm1(cre)Sato/Kdr⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0008097	increased plasma cell number	"greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Traf3ip2^tm2Sbn/Traf3ip2^tm2Sbn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
MP:0008099	abnormal plasma cell differentiation	"atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺,Tg(BCL2)22Wehi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6JWehi * SJL/JWehi
MP:0008168	decreased B-1a cell number	"reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺,Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/? Genetic Background: involves: BALB/c * C57BL/6 * NZB Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj
MP:0008169	increased B-1b cell number	"greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0008170	decreased B-1b cell number	"reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]	Show Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj
MP:0008173	increased follicular B cell number	"greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008174	decreased follicular B cell number	"reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008177	increased germinal center B cell number	"greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk,Traf3ip2^tm2Sbn/Traf3ip2^tm2Sbn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6
MP:0008178	decreased germinal center B cell number	"reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]	Show Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl * DBA/2
MP:0008181	increased marginal zone B cell number	"greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0008182	decreased marginal zone B cell number	"reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Ubc-BCL3)Sbn}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008186	increased pro-B cell number	"greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1.1Cgn/Cd79a⁺,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0008189	increased transitional stage B cell number	"greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito,Reck^tm1Ito/Reck^tm1Ito Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6
MP:0008190	decreased transitional stage B cell number	"reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn,Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak
MP:0008193	abnormal marginal zone B cell physiology	"abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0008194	abnormal memory B cell physiology	"abnormal function of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6JJcl
MP:0008203	absent B-1a cells	"absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srsf3^tm1Pjln/Srsf3^tm1Pjln,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Dnmt1^tm2Jae/Dnmt1^tm2Jae,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Hdac1^tm1.1Pmt/Hdac1^tm1.1Pmt,Hdac2^tm1.1Pmt/Hdac2^tm1.1Pmt,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N Allelic Composition: Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu,Cd79a^tm1(cre)Reth/Cd79a⁺,Rag2^tm1Fwa/Rag2^tm1Fwa Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Srsf3^tm1Pjln/Srsf3^tm1Pjln,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn Genetic Background: involves: C57BL/6 Allelic Composition: Hdac1^tm1.1Pmt/Hdac1^tm1.1Pmt,Hdac2^tm1.1Pmt/Hdac2^tm1.1Pmt,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm1Gzmn/Cd79b⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1.1Cgn/Cd79a⁺,Cd79b^tm1Gzmn/Cd79b^tm1Gzmn Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dynll1^tm1.1Jhh/Dynll1^tm1.1Jhh Genetic Background: B6.Cg-Dynll1^tm1.1Jhh Cd79a^tm1(Cre)Reth
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn Genetic Background: involves: C57BL/6 * C.B-20 Allelic Composition: Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk,Tg(IghelMD4)4Ccg/0,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dicer1^tm1Mmk/Dicer1^tm1Mmk,Tg(BCL2)22Wehi/0 Genetic Background: involves: BALB/c * C57BL/6JWehi * SJL/JWehi Allelic Composition: Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Dicer1^tm1Mmk/Dicer1^tm1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Was^tm1.1Ldn Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Was^tm1.1Ldn/Y Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dynll1^tm1.1Jhh/Dynll1^tm1.1Jhh Genetic Background: B6.Cg-Dynll1^tm1.1Jhh Cd79a^tm1(Cre)Reth
MP:0008212	absent mature B cells	"absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: P2rx2^tm1Ckn/P2rx2^tm1Ckn,P2rx3^tm1Ckn/P2rx3^tm1Ckn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn,Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0008213	absent immature B cells	"absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm5Cgn/Cd79a^tm5.1Cgn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008214	increased immature B cell number	"greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Trp53^tm1Brn/Trp53^tm1Brn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dynll1^tm1.1Jhh/Dynll1^tm1.1Jhh Genetic Background: B6.Cg-Dynll1^tm1.1Jhh Cd79a^tm1(Cre)Reth Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dynll1^tm1.1Jhh/Dynll1^tm1.1Jhh,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Dynll1^tm1.1Jhh Cd79a^tm1(Cre)Reth Tg(IghMyc)22Bri Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008217	abnormal B cell activation	"any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008233	abnormal pro-B cell differentiation	"atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd22^tm1Lam/Cd22^tm1Lam,Igh^tm1.2Rsky/Igh^tm1.2Rsky Genetic Background: involves: 129 * BALB/c * C57BL/6 Allelic Composition: Syk^tm1Kuro/Syk^tm1Kuro,Zap70^tm1Dlo/Zap70^tm1Dlo,Cd79a^tm1(cre)Reth/? Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0008240	abnormal spleen marginal zone macrophage morphology	"any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation" [PMID:16322748]	Show Allelic Composition: Cd79a^tm3Cgn/Cd79a^tm3Cgn,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: C57BL/6 * CBA
MP:0008241	abnormal metallophilic macrophage morphology	"any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]	Show Allelic Composition: Cd79a^tm3Cgn/Cd79a^tm3Cgn,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: C57BL/6 * CBA
MP:0008482	decreased spleen germinal center number	"reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ
MP:0008484	decreased spleen germinal center size	"reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0008496	decreased IgG2a level	"less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj
MP:0008497	decreased IgG2b level	"less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Rnf31^tm1.1Kiwa/Rnf31^tm1.1Kiwa,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0008501	increased IgG2b level	"greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008577	increased circulating interferon-gamma level	"increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008593	increased circulating interleukin-10 level	"increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008660	increased interleukin-10 secretion	"increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008661	decreased interleukin-10 secretion	"reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008681	increased interleukin-17 secretion	"increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Stim1^tm1Kuro/Stim1^tm1Kuro,Stim2^tm1.1Kuro/Stim2^tm1.1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008688	decreased interleukin-2 secretion	"reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Nfatc2^tm1Rao/Nfatc2^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0008713	abnormal cytokine level	"deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0008755	abnormal immunoglobulin V(D)J recombination	"any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033152, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1Mmk/Dicer1^tm1.1Mmk,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c
MP:0008782	increased B cell apoptosis	"increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hdac1^tm1.1Pmt/Hdac1^tm1.1Pmt,Hdac2^tm1.1Pmt/Hdac2^tm1.1Pmt,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Huwe1^tm1.1Mak/Y Genetic Background: B6.Cg-Cd79a^tm1(cre)Reth Huwe1^tm1.1Mak Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0008896	increased IgG2c level	"greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6
MP:0008897	decreased IgG2c level	"less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6 Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J
MP:0009339	decreased splenocyte number	"reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(CAG-Notch2)Uzs}/Gt(ROSA)26Sor⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background:* involves: 129S6/SvEvTac * BALB/c * C57BL/6J
MP:0009828	delayed tumor appearance	"later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0009922	increased transitional stage T1 B cell number	"greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6
MP:0009923	decreased transitional stage T1 B cell number	"reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ
MP:0009925	increased transitional stage T2 B cell number	"greater number of a type of a transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6
MP:0009926	decreased transitional stage T2 B cell number	"reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]	Show Allelic Composition: Grb2^tm1Lnit/Grb2^tm1Lnit,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * BALB/cJ Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB
MP:0010209	abnormal circulating chemokine level	"deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(ETV6/SYK)Hjum}/Gt(ROSA)26Sor⁺,Cd79a^{tm3(cre/ERT2)Reth}/Cd79a⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0010228	decreased transitional stage T3 B cell number	"reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]	Show Allelic Composition: Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 * NZB
MP:0010229	increased transitional stage T3 B cell number	"greater number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive" [PMID:12810111]	Show Allelic Composition: Cd79a^tm1Rsky/Cd79a^tm1Rsky Genetic Background: involves: C57BL/6
MP:0010268	decreased lymphoma incidence	"less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺,Dynll1^tm1.1Jhh/Dynll1^tm1.1Jhh,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Dynll1^tm1.1Jhh Cd79a^tm1(Cre)Reth Tg(IghMyc)22Bri Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0014050	increased B cell acute lymphoblastic leukemia incidence	"an aggressive (fast-growing) type of leukemia (blood cancer) in which too many B-cell lymphoblasts (immature white blood cells) are found in the bone marrow and blood; it is the most common type of acute lymphoblastic leukemia (ALL)" [NCIT:C8644]	Show Allelic Composition: Tcf3^tm1(PBX1)Mlc/Tcf3⁺,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0020154	impaired humoral immune response	"impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]	Show Allelic Composition: Cd79a^m2Btlr/Cd79a^m2Btlr Genetic Background: C57BL/6J-Cd79a^m2Btlr

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

ENSMUSG00000003379