ENSMUSG00000040592


Mus musculus

Features
Gene ID: ENSMUSG00000040592
  
Biological name :Cd79b
  
Synonyms : B-cell antigen receptor complex-associated protein beta chain / Cd79b / P15530
  
Possible biological names infered from orthology : CD79b molecule / P40259
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 106311341
Gene end: 106314762
  
Corresponding Affymetrix probe sets: 10392142 (MoGene1.0st)   1417640_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048239
Ensembl peptide - ENSMUSP00000129029
NCBI entrez gene - 15985     See in Manteia.
MGI - MGI:96431
RefSeq - NM_001313939
RefSeq - NM_008339
RefSeq Peptide - NP_001300868
RefSeq Peptide - NP_032365
swissprot - P15530
swissprot - B1ARJ9
Ensembl - ENSMUSG00000040592
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD79BENSGALG00000000251Gallus gallus
 CD79BENSG00000007312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003110  Phosphorylated immunoreceptor signalling ITAM
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0030183 B cell differentiation IBA
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0019815 B cell receptor complex IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
CD22 mediated BCR regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: P2rx2tm1Ckn/P2rx2tm1Ckn,P2rx3tm1Ckn/P2rx3tm1Ckn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic Background: B6.129S7-Trp53tm3.1Glo

Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn,Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79bm1Ghost/Cd79bm1Ghost
Genetic Background: B10.Cg-Ptprca Cd79bm1Ghost H2a

Allelic Composition: Cd79btm1Mnz/Cd79btm1Mnz
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cd79btm1Mnz/Cd79btm1Mnz,Tg(IghelMD4)4Ccg/0,Tg(Rag2-Igb)1Mnz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cd79btm1Mnz/Cd79btm1Mnz,Tg(BCL2)22Wehi/0,Tg(Rag2-Igb)1Mnz/0
Genetic Background: involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi

Allelic Composition: Cd79btm1Mnz/Cd79btm1Mnz,Tg(BCL2)22Wehi/0,Tg(IghelMD4)4Ccg/0,Tg(Rag2-Igb)1Mnz/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79bm1Ghost/Cd79bm1Ghost
Genetic Background: B10.Cg-Ptprca Cd79bm1Ghost H2a

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79bm1Ghost/Cd79bm1Ghost
Genetic Background: B10.Cg-Ptprca Cd79bm1Ghost H2a

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic Background: B6.129S7-Trp53tm3.1Glo

Allelic Composition: Cd79bm1Ghost/Cd79bm1Ghost
Genetic Background: B10.Cg-Ptprca Cd79bm1Ghost H2a

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/Gt(ROSA)26Sortm1(SNCA*A53T)Djmo
Genetic Background: involves: 129 * C57BL/6J

 MP:0002403 abnormal pre-B cell "anomalous structure, development, or number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brd/Trp53+,Tg(Rbp3-cre)1Brn/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic Background: B6.129S7-Trp53tm3.1Glo

 MP:0002496 increased IgD "greater than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic Background: B6.129S7-Trp53tm3.1Glo

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd79bm1Ghost/Cd79bm1Ghost
Genetic Background: B10.Cg-Ptprca Cd79bm1Ghost H2a

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm1Gzmn/Cd79b+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd79atm1.1Cgn/Cd79a+,Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005022 abnormal immature B cell "anomalous structure, development, or number of the cells of the B lymphocyte lineage that have undergone VDJ rearragnement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79btm1Mnz/Cd79btm1Mnz,Tg(IghelMD4)4Ccg/0,Tg(Rag2-Igb)1Mnz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79btm1Mnz/Cd79btm1Mnz
Genetic Background: involves: 129S1/Sv

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79bm1Ghost/Cd79bm1Ghost
Genetic Background: B10.Cg-Ptprca Cd79bm1Ghost H2a

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic Background: B6.129S7-Trp53tm3.1Glo

Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm1Gzmn/Cd79b+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd79atm1.1Cgn/Cd79a+,Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic Background: involves: 129P2/OlaHsd

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn,Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm1Gzmn/Cd79b+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd79atm1.1Cgn/Cd79a+,Cd79btm1Gzmn/Cd79btm1Gzmn
Genetic Background: involves: 129P2/OlaHsd

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008212 absent mature B cells "absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm1.1Cgn/Cd79atm1.1Cgn,Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79btm3Mnz/Cd79btm3Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79btm2.1Mnz/Cd79btm2.1Mnz
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79btm1Mnz/Cd79btm1Mnz
Genetic Background: involves: 129S1/Sv

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic Background: B6.129S7-Trp53tm3.1Glo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003379 Cd79a / P11911 / B-cell antigen receptor complex-associated protein alpha chain / P11912* / CD79a molecule*  / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / complex / reaction
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000076937 Iglc2 / P01844 / Ig lambda-2 chain C region   / complex






 

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