ENSGALG00000001409


Gallus gallus

Features
Gene ID: ENSGALG00000001409
  
Biological name :IL12B
  
Synonyms : IL12B / interleukin-12 subunit beta precursor
  
Possible biological names infered from orthology : interleukin 12B / Interleukin-12 subunit beta / P29460 / P43432
  
Species: Gallus gallus
  
Chr. number: 13
Strand: 1
Band:
Gene start: 8148378
Gene end: 8157639
  
Corresponding Affymetrix probe sets: Gga.14433.1.S1_at (Chicken Array)   Gga.14433.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000040257
Ensembl peptide - ENSGALP00000002143
NCBI entrez gene - 404671     See in Manteia.
RefSeq - XM_015293642
RefSeq - NM_213571
RefSeq - XM_015293640
RefSeq - XM_015293641
RefSeq Peptide - NP_998736
swissprot - F6VIW7
swissprot - A0A1L1U0X1
Ensembl - ENSGALG00000001409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il12baENSDARG00000033727Danio rerio
 il12bbENSDARG00000054542Danio rerio
 IL12BENSG00000113302Homo sapiens
 Il12bENSMUSG00000004296Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015528  Interleukin-12 beta
 IPR019482  Interleukin-12 beta, central domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
 biological_processGO:0002862 negative regulation of inflammatory response to antigenic stimulus IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010224 response to UV-B IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030101 natural killer cell activation IEA
 biological_processGO:0032609 interferon-gamma production IEA
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production IEA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032816 positive regulation of natural killer cell activation IEA
 biological_processGO:0032819 positive regulation of natural killer cell proliferation IEA
 biological_processGO:0032946 positive regulation of mononuclear cell proliferation IEA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035744 T-helper 1 cell cytokine production IEA
 biological_processGO:0042093 T-helper cell differentiation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042509 regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042832 defense response to protozoan IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0051135 positive regulation of NK T cell activation IEA
 biological_processGO:0051142 positive regulation of NK T cell proliferation IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043514 interleukin-12 complex IEA
 cellular_componentGO:0070743 interleukin-23 complex IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042164 interleukin-12 alpha subunit binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045519 interleukin-23 receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-12 signaling
Interleukin-23 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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