ENSMUSG00000030166


Mus musculus

Features
Gene ID: ENSMUSG00000030166
  
Biological name :Rad52
  
Synonyms : P43352 / Rad52 / RAD52 homolog, DNA repair protein
  
Possible biological names infered from orthology : P43351
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 119902698
Gene end: 119922828
  
Corresponding Affymetrix probe sets: 10541191 (MoGene1.0st)   1416602_a_at (Mouse Genome 430 2.0 Array)   1426296_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032269
Ensembl peptide - ENSMUSP00000125502
Ensembl peptide - ENSMUSP00000125559
NCBI entrez gene - 19365     See in Manteia.
MGI - MGI:101949
RefSeq - XM_011241256
RefSeq - NM_001166382
RefSeq - NM_001166383
RefSeq - NM_011236
RefSeq - XM_006505764
RefSeq - XM_006505765
RefSeq - XM_006505766
RefSeq - XM_006505767
RefSeq - NM_001166381
RefSeq Peptide - NP_035366
RefSeq Peptide - NP_001159853
RefSeq Peptide - NP_001159854
RefSeq Peptide - NP_001159855
swissprot - P43352
swissprot - G5E879
swissprot - E0CZA6
Ensembl - ENSMUSG00000030166
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad52ENSDARG00000005274Danio rerio
 RAD52ENSGALG00000039171Gallus gallus
 RAD52ENSG00000002016Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004585  DNA recombination/repair protein Rad52
 IPR007232  DNA repair protein Rad52/59/22


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0000730 DNA recombinase assembly IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0010792 DNA double-strand break processing involved in repair via single-strand annealing IMP
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0045002 double-strand break repair via single-strand annealing IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:2000819 regulation of nucleotide-excision repair ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000030166 Rad52 / P43352 / RAD52 homolog, DNA repair protein / P43351*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

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