ENSMUSG00000021638


Mus musculus

Features
Gene ID: ENSMUSG00000021638
  
Biological name :Ocln
  
Synonyms : occludin / Ocln / Q61146
  
Possible biological names infered from orthology : Q16625
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 100496507
Gene end: 100552718
  
Corresponding Affymetrix probe sets: 10411668 (MoGene1.0st)   1440220_at (Mouse Genome 430 2.0 Array)   1448873_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065284
Ensembl peptide - ENSMUSP00000125642
Ensembl peptide - ENSMUSP00000125595
Ensembl peptide - ENSMUSP00000124849
Ensembl peptide - ENSMUSP00000022140
NCBI entrez gene - 18260     See in Manteia.
MGI - MGI:106183
RefSeq - XM_006517563
RefSeq - XM_011244634
RefSeq - XM_006517566
RefSeq - NM_008756
RefSeq - XM_006517564
RefSeq Peptide - NP_032782
swissprot - Q61146
swissprot - E0CZ91
swissprot - B2RS24
swissprot - E0CZ73
Ensembl - ENSMUSG00000021638
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oclnaENSDARG00000005108Danio rerio
 oclnbENSDARG00000003091Danio rerio
 OCLNENSGALG00000037316Gallus gallus
 OCLNENSG00000197822Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002958  Occludin
 IPR008253  Marvel domain
 IPR010844  Occludin homology domain
 IPR031176  ELL/occludin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045216 cell-cell junction organization ISO
 biological_processGO:0070673 response to interleukin-18 IEA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016327 apicolateral plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cell adhesion proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mostm1Gvw/Mostm1Gvw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: OclnGt(ROSA)39Tshi/OclnGt(ROSA)39Tshi
Genetic Background: involves: DBA/2

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: OclnGt(ROSA)39Tshi/OclnGt(ROSA)39Tshi
Genetic Background: involves: DBA/2

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: OclnGt(ROSA)39Tshi/OclnGt(ROSA)39Tshi
Genetic Background: involves: DBA/2

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: OclnGt(ROSA)39Tshi/OclnGt(ROSA)39Tshi
Genetic Background: involves: DBA/2

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Oclntm1Sts/Oclntm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009517 abnormal salivary gland duct morphology "any structural anomaly of the tubular canals that carry saliva" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: OclnGt(ROSA)39Tshi/OclnGt(ROSA)39Tshi
Genetic Background: involves: DBA/2

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010779 abnormal stomach muscularis externa morphology "any structural anomaly of the smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: OclnGt(ROSA)39Tshi/OclnGt(ROSA)39Tshi
Genetic Background: involves: DBA/2

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: OclnGt(ROSA)39Tshi/OclnGt(ROSA)39Tshi
Genetic Background: involves: DBA/2

Allelic Composition: Oclntm1Tshi/Oclntm1Tshi
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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