ENSMUSG00000018411


Mus musculus

Features
Gene ID: ENSMUSG00000018411
  
Biological name :Mapt
  
Synonyms : Mapt / Microtubule-associated protein tau / P10637
  
Possible biological names infered from orthology : P10636
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 104231390
Gene end: 104332090
  
Corresponding Affymetrix probe sets: 10381776 (MoGene1.0st)   1417885_at (Mouse Genome 430 2.0 Array)   1424718_at (Mouse Genome 430 2.0 Array)   1424719_a_at (Mouse Genome 430 2.0 Array)   1455028_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102602
Ensembl peptide - ENSMUSP00000102601
Ensembl peptide - ENSMUSP00000102605
Ensembl peptide - ENSMUSP00000123260
Ensembl peptide - ENSMUSP00000119145
Ensembl peptide - ENSMUSP00000114716
Ensembl peptide - ENSMUSP00000102606
Ensembl peptide - ENSMUSP00000097919
NCBI entrez gene - 17762     See in Manteia.
MGI - MGI:97180
RefSeq - XM_006532410
RefSeq - NM_001038609
RefSeq - NM_001285454
RefSeq - NM_001285455
RefSeq - NM_001285456
RefSeq - NM_010838
RefSeq - XM_006532407
RefSeq - XM_006532408
RefSeq - XM_006532409
RefSeq Peptide - NP_001033698
RefSeq Peptide - NP_001272383
RefSeq Peptide - NP_001272385
RefSeq Peptide - NP_034968
RefSeq Peptide - NP_001272384
swissprot - B1AQW2
swissprot - A2A5Y6
swissprot - Q547J4
swissprot - P10637
swissprot - A0A0A0MQC7
swissprot - B1AQW6
swissprot - B1AQW5
swissprot - B1AQW4
Ensembl - ENSMUSG00000018411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maptaENSDARG00000089314Danio rerio
 maptbENSDARG00000087616Danio rerio
 MAPTENSGALG00000000625Gallus gallus
 MAPTENSG00000186868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map2 / P20357 / Microtubule-associated protein 2 / P11137*ENSMUSG0000001522240
Map4 / P27546 / Microtubule-associated protein 4 / P27816*ENSMUSG0000003247934


Protein motifs (from Interpro)
Interpro ID Name
 IPR001084  Microtubule associated protein, tubulin-binding repeat
 IPR002955  Microtubule-associated protein Tau


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007409 axonogenesis IGI
 biological_processGO:0007416 synapse assembly ISO
 biological_processGO:0007611 learning or memory ISO
 biological_processGO:0007613 memory IEA
 biological_processGO:0007628 adult walking behavior IGI
 biological_processGO:0008088 axo-dendritic transport IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010917 negative regulation of mitochondrial membrane potential IEA
 biological_processGO:0031110 regulation of microtubule polymerization or depolymerization IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0032387 negative regulation of intracellular transport IMP
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0047497 mitochondrion transport along microtubule IMP
 biological_processGO:0048312 intracellular distribution of mitochondria IEA
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050848 regulation of calcium-mediated signaling IEA
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0060632 regulation of microtubule-based movement IDA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0090258 negative regulation of mitochondrial fission IEA
 biological_processGO:0097435 supramolecular fiber organization IEA
 biological_processGO:1900034 regulation of cellular response to heat IMP
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902474 positive regulation of protein localization to synapse IEA
 biological_processGO:1903748 negative regulation of establishment of protein localization to mitochondrion IEA
 biological_processGO:1903829 positive regulation of cellular protein localization IEA
 biological_processGO:1904428 negative regulation of tubulin deacetylation IGI
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:2001020 regulation of response to DNA damage stimulus IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005875 microtubule associated complex IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0034399 nuclear periphery IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045298 tubulin complex IEA
 cellular_componentGO:0097418 neurofibrillary tangle IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0034185 apolipoprotein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048018 receptor ligand activity IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0071813 lipoprotein particle binding IEA
 molecular_functionGO:0099609 microtubule lateral binding IEA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-27H/KitW-27H
Genetic Background: CBA/H-KitW-27H

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pclotm3.3Sud/Pclotm3.3Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Mapttm2.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm2.1(FUS)Neas

Allelic Composition: Chattm2(cre)Lowl/Chat+,Mapttm3(FUS)Neas/Mapt+
Genetic Background: B6.129-Mapttm3(FUS)Neas Chattm2(cre)Lowl

Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Rasgrf1tm1Toc/Rasgrf1tm1Toc
Genetic Background: involves: 129/Sv

Allelic Composition: Mapttm2.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm2.1(FUS)Neas

Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Mapttm2Arbr/Mapt+,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Mapttm2Arbr/?,Runx1tm3Spe/Runx1tm3Spe,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J

 MP:0000969 abnormal nociceptor morphology "anomalous structure of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000972 abnormal mechanoreceptor morphology "anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:34172]
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Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Mapttm2Arbr/?,Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Chattm2(cre)Lowl/Chat+,Mapttm2(FUS)Neas/Mapt+
Genetic Background: B6.129-Mapttm2(FUS)Neas Chattm2(cre)Lowl

Allelic Composition: Mapttm2.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm2.1(FUS)Neas

Allelic Composition: Chattm2(cre)Lowl/Chat+,Mapttm3(FUS)Neas/Mapt+
Genetic Background: B6.129-Mapttm3(FUS)Neas Chattm2(cre)Lowl

Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

Allelic Composition: Mapttm3.1(FUS)Neas/Mapttm3.1(FUS)Neas
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

Allelic Composition: Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi,Mapttm3.1(FUS)Neas/Mapt+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129 * C3H * C57BL/6 * C57BL/6N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Dok2tm1Ppp/Dok2+
Genetic Background: 129S1/Sv-Dok2tm1Ppp

Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: KitW-27H/KitW-27H
Genetic Background: CBA/H-KitW-27H

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Arntltm1.1Ljm/Arntltm1.1Ljm,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

Allelic Composition: Mapttm1(Setdb1)Akba/Mapt+,Mecp2tm1Jae/Y,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba,Mecp2tm1Jae/Y,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapttm1Hnd/Mapt+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Bdnftm1Msd/Bdnftm1Msd,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

Allelic Composition: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Genetic Background: B6.129S4-Mapttm1(EGFP)Klt

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dido1tm1Cmar/Dido1tm2Cmar
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen/Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen
Genetic Background: B6.Cg-Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

Allelic Composition: Mapttm1(Setdb1)Akba/Mapt+,Mecp2tm1Jae/Y,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba,Mecp2tm1Jae/Y,Tg(Nes-cre)1Atp/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ywhaetm1Awb/Ywhae+
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

Allelic Composition: Mapttm1(Mecp2)Jae/Mapt+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mapttm3(cre/PGR)Aha/Mapttm3(cre/PGR)Aha
Genetic Background: Not Specified

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: KitW-27H/KitW-27H
Genetic Background: CBA/H-KitW-27H

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Genetic Background: B6.129S4-Mapttm1(EGFP)Klt

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Mapttm1Hnd/Mapt+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Mapttm1Hnd/Mapt+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Mapttm1Hnd/Mapt+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

 MP:0002915 abnormal synaptic depression "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
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Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Pclotm3.3Sud/Pclotm3.3Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003214 neurofibrillary tangles "dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NOD * SJL

Allelic Composition: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Mapttm1Hnd/Mapt+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapttm2.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm2.1(FUS)Neas

Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Mapttm2Arbr/Mapt+,Shox2tm1.1(cre)Oki/Shox2+,Slc17a6tm1.1Thna/Slc17a6tm1.2Edw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
Genetic Background: involves: FVB/N

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic Background: B6.Cg-Mapttm1(Mecp2)Jae

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arntltm1.1Ljm/Arntltm1.1Ljm,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Notch1tm2Agt/Notch1tm2Agt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

Allelic Composition: Mapttm1Aha/Mapttm1Aha
Genetic Background: Not Specified

Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Mapttm2Arbr/?,Runx1tm3Spe/Runx1tm3Spe,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J

 MP:0006006 increased sensory neuron number "greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1Hnd/Mapttm1Hnd
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
Genetic Background: involves: FVB/N

Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008282 enlarged hippocampus "increased size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
Genetic Background: involves: FVB/N

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Mapttm1(Sema3e)Yuyo/Mapt+,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: Not Specified

Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm2.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm2.1(FUS)Neas

Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Pclotm3.3Sud/Pclotm3.3Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009317 follicular lymphoma "malignant lymphoma arising from lymphoid follicular B cells which may be small or large" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm3.1(FUS)Neas/Mapt+
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Genetic Background: B6.129S4-Mapttm1(EGFP)Klt

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Genetic Background: B6.129S4-Mapttm1(EGFP)Klt

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mapttm1Hnd/Mapttm1Hnd,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Mapttm1Hnd/Mapt+,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
Genetic Background: involves: FVB/N

Allelic Composition: Mapttm2(Hdac1)Jae/Mapttm2(Hdac1)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Mapkap1tm1b(EUCOMM)Wtsi/Mapkap1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mapkap1tm1b(EUCOMM)Wtsi/Bay

 MP:0012306 enhanced spatial learning "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Genetic Background: B6.129S4-Mapttm1(EGFP)Klt

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
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Allelic Composition: Bdnftm1Yab/Bdnftm1Yab,Mapttm1(cre)Nagy/Mapt+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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