ENSMUSG00000015222


Mus musculus

Features
Gene ID: ENSMUSG00000015222
  
Biological name :Map2
  
Synonyms : Map2 / Microtubule-associated protein 2 / P20357
  
Possible biological names infered from orthology : P11137
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 66175273
Gene end: 66442583
  
Corresponding Affymetrix probe sets: 10347036 (MoGene1.0st)   1421327_at (Mouse Genome 430 2.0 Array)   1421328_at (Mouse Genome 430 2.0 Array)   1434194_at (Mouse Genome 430 2.0 Array)   1440699_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134651
Ensembl peptide - ENSMUSP00000134518
Ensembl peptide - ENSMUSP00000134538
Ensembl peptide - ENSMUSP00000024639
Ensembl peptide - ENSMUSP00000076577
Ensembl peptide - ENSMUSP00000109645
Ensembl peptide - ENSMUSP00000109646
Ensembl peptide - ENSMUSP00000109648
Ensembl peptide - ENSMUSP00000109650
Ensembl peptide - ENSMUSP00000109651
Ensembl peptide - ENSMUSP00000117996
Ensembl peptide - ENSMUSP00000119341
Ensembl peptide - ENSMUSP00000133446
Ensembl peptide - ENSMUSP00000133871
Ensembl peptide - ENSMUSP00000134187
Ensembl peptide - ENSMUSP00000134471
NCBI entrez gene - 17756     See in Manteia.
MGI - MGI:97175
RefSeq - XM_017319194
RefSeq - XM_006495751
RefSeq - XM_006495752
RefSeq - XM_006495753
RefSeq - XM_006495754
RefSeq - XM_006495756
RefSeq - XM_006495757
RefSeq - XM_006495758
RefSeq - XM_006495759
RefSeq - XM_006495760
RefSeq - XM_006495761
RefSeq - XM_006495762
RefSeq - XM_011238448
RefSeq - XM_017319165
RefSeq - XM_017319166
RefSeq - XM_017319169
RefSeq - XM_017319175
RefSeq - NM_001039934
RefSeq - NM_001310634
RefSeq - NM_008632
RefSeq - XM_006495746
RefSeq - XM_006495747
RefSeq - XM_006495748
RefSeq - XM_006495749
RefSeq - XM_006495750
RefSeq Peptide - NP_032658
RefSeq Peptide - NP_001035023
RefSeq Peptide - NP_001297563
swissprot - G3UZE9
swissprot - G3UZJ2
swissprot - G3UZK9
swissprot - G3UZV6
swissprot - F7ALC8
swissprot - Q80X35
swissprot - Q80ZL4
swissprot - E9Q8Y2
swissprot - P20357
swissprot - G3UWW1
swissprot - Q3TLQ0
swissprot - G3UXY3
swissprot - G3UYR3
Ensembl - ENSMUSG00000015222
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000002789Gallus gallus
 MAP2ENSG00000078018Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map4 / P27546 / Microtubule-associated protein 4 / P27816*ENSMUSG0000003247912
Mapt / P10637 / Microtubule-associated protein tau / P10636*ENSMUSG000000184119


Protein motifs (from Interpro)
Interpro ID Name
 IPR001084  Microtubule associated protein, tubulin-binding repeat
 IPR013588  MAP2/Tau projection
 IPR018459  RII binding domain
 IPR030797  Microtubule-associated protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0021954 central nervous system neuron development IEA
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0071310 cellular response to organic substance IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex TAS
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0034399 nuclear periphery IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0097442 CA3 pyramidal cell dendrite IDA
 molecular_functionGO:0002162 dystroglycan binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005519 cytoskeletal regulatory protein binding TAS
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0015631 tubulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002208 abnormal germ cell morphology "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003684 abnormal inferior olivary complex "any structural abnormality in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Map2repro4/Map2repro4
Genetic Background: C3.B6-Map2repro4

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map2repro4/Map2repro4
Genetic Background: C3.B6-Map2repro4

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2repro4/Map2repro4
Genetic Background: C3.B6-Map2repro4

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Map2repro4/Map2repro4
Genetic Background: C3.B6-Map2repro4

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2repro4/Map2repro4
Genetic Background: C3.B6-Map2repro4

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Map1btm1Noh/Map1btm1Noh,Map2tm1Noh/Map2tm1Noh
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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