ENSMUSG00000026879


Mus musculus

Features
Gene ID: ENSMUSG00000026879
  
Biological name :Gsn
  
Synonyms : gelsolin / Gsn / P13020
  
Possible biological names infered from orthology : P06396
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 35256380
Gene end: 35307892
  
Corresponding Affymetrix probe sets: 10471655 (MoGene1.0st)   1415812_at (Mouse Genome 430 2.0 Array)   1436991_x_at (Mouse Genome 430 2.0 Array)   1437171_x_at (Mouse Genome 430 2.0 Array)   1456312_x_at (Mouse Genome 430 2.0 Array)   1456568_at (Mouse Genome 430 2.0 Array)   1456569_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144296
Ensembl peptide - ENSMUSP00000144217
Ensembl peptide - ENSMUSP00000144470
Ensembl peptide - ENSMUSP00000144561
Ensembl peptide - ENSMUSP00000028239
Ensembl peptide - ENSMUSP00000118120
NCBI entrez gene - 227753     See in Manteia.
MGI - MGI:95851
RefSeq - XM_006497993
RefSeq - NM_001206367
RefSeq - NM_001206368
RefSeq - NM_001206369
RefSeq - NM_146120
RefSeq - XM_006497990
RefSeq - XM_006497991
RefSeq - XM_006497992
RefSeq Peptide - NP_001193296
RefSeq Peptide - NP_001193298
RefSeq Peptide - NP_666232
RefSeq Peptide - NP_001193297
swissprot - A0A0J9YUJ8
swissprot - P13020
swissprot - Q6PAC1
swissprot - A6PWS5
swissprot - A0A0J9YUQ8
Ensembl - ENSMUSG00000026879
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsnaENSDARG00000011459Danio rerio
 gsnbENSDARG00000045262Danio rerio
 GSNENSGALG00000001446Gallus gallus
 GSNENSG00000148180Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scin / Q60604 / scinderin / Q9Y6U3*ENSMUSG0000000256555
Vil1 / Q62468 / villin 1 / P09327*ENSMUSG0000002617546
Avil / O88398 / Advillin / O75366*ENSMUSG0000002543244
Vill / Q91YD6 / villin-like / O15195*ENSMUSG0000003877533
Flii / Q9JJ28 / isoform 2 / Q13045* / FLII, actin remodeling protein*ENSMUSG0000000281228
Svil / Q8K4L3 / supervillin / O95425*ENSMUSG0000002423626
Capg / capping actin protein, gelsolin like / P40121*ENSMUSG0000005673722


Protein motifs (from Interpro)
Interpro ID Name
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR030004  Gelsolin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0014891 striated muscle atrophy IEA
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0042989 sequestering of actin monomers IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0051014 actin filament severing ISO
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051127 positive regulation of actin nucleation IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0051693 actin filament capping ISO
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071801 regulation of podosome assembly IEA
 biological_processGO:0090527 actin filament reorganization IEA
 biological_processGO:0097017 renal protein absorption IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1902174 positive regulation of keratinocyte apoptotic process IEA
 biological_processGO:1903903 regulation of establishment of T cell polarity IEA
 biological_processGO:1903906 regulation of plasma membrane raft polarization IEA
 biological_processGO:1903909 regulation of receptor clustering IEA
 biological_processGO:1903923 positive regulation of protein processing in phagocytic vesicle IMP
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016528 sarcoplasm IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030478 actin cap IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045159 myosin II binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002295 abnormal pulmonary circulation "anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcl1tm2Sjk/Mcl1tm3Sjk,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0013782 abnormal mammary duct terminal end bud morphology "any structural anomaly of the unique club-shaped epithelial structure that develops at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; terminal end buds (TEBs) consist of an outer layer of undifferentiated myoepithelial progenitor cells (cap cells), and a multilayered inner core of luminal epithelial cells (body) fated to form the walls of the ductal lumen; both layers have high rates of mitosis, consistent with a motile organ dedicated to ductal morphogenesis; TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed" [MGI:Anna, PMID:16280048, PMID:16916375, PMID:18296651]
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Allelic Composition: Prkacatm1Gsm/Prkacatm1Gsm,Prkacbtm1Gsm/Prkacb+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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