ENSMUSG00000025432


Mus musculus

Features
Gene ID: ENSMUSG00000025432
  
Biological name :Avil
  
Synonyms : Advillin / Avil / O88398
  
Possible biological names infered from orthology : O75366
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127000709
Gene end: 127020994
  
Corresponding Affymetrix probe sets: 10366774 (MoGene1.0st)   1419148_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123405
Ensembl peptide - ENSMUSP00000026500
Ensembl peptide - ENSMUSP00000115018
Ensembl peptide - ENSMUSP00000117667
NCBI entrez gene - 11567     See in Manteia.
MGI - MGI:1333798
RefSeq - XM_006513102
RefSeq - XM_006513098
RefSeq - XM_006513099
RefSeq - XM_006513100
RefSeq - XM_006513101
RefSeq - NM_009635
RefSeq - XM_006513097
RefSeq Peptide - NP_033765
swissprot - D3Z3N6
swissprot - D3YXP4
swissprot - O88398
Ensembl - ENSMUSG00000025432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 avilENSDARG00000059342Danio rerio
 AVILENSG00000135407Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vil1 / Q62468 / villin 1 / P09327*ENSMUSG0000002617560
Vill / Q91YD6 / villin-like / O15195*ENSMUSG0000003877546
Gsn / P13020 / gelsolin / P06396*ENSMUSG0000002687942
Scin / Q60604 / scinderin / Q9Y6U3*ENSMUSG0000000256542
Svil / Q8K4L3 / supervillin / O95425*ENSMUSG0000002423628
Flii / Q9JJ28 / isoform 2 / Q13045* / FLII, actin remodeling protein*ENSMUSG0000000281227
Capg / capping actin protein, gelsolin like / P40121*ENSMUSG0000005673718


Protein motifs (from Interpro)
Interpro ID Name
 IPR003128  Villin headpiece
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR036180  Gelsolin-like domain superfamily
 IPR036886  Villin headpiece domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007015 actin filament organization ISS
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0060271 cilium assembly ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection ISS
 cellular_componentGO:0043005 neuron projection ISS
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ano1tm1.1Jwo/Ano1tm1.1Jwo,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Ntrk2tm4.1Ddg/Ntrk2tm4.1Ddg,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Stard13tm1.2Fms/Stard13tm1.2Fms
Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gdnftm1Lmgd/Gdnf+,Kif26btm1.1Ryn/Kif26b+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0030012 impaired central nervous system regeneration "reduced or delayed ability to regenerate healthy central nervous system tissue following injury or disease" [MGI:anna]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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