ENSMUSG00000024236


Mus musculus

Features
Gene ID: ENSMUSG00000024236
  
Biological name :Svil
  
Synonyms : Q8K4L3 / supervillin / Svil
  
Possible biological names infered from orthology : O95425
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 4920540
Gene end: 5119299
  
Corresponding Affymetrix probe sets: 10453636 (MoGene1.0st)   1460694_s_at (Mouse Genome 430 2.0 Array)   1460735_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121972
Ensembl peptide - ENSMUSP00000121497
Ensembl peptide - ENSMUSP00000122242
Ensembl peptide - ENSMUSP00000147843
Ensembl peptide - ENSMUSP00000025079
Ensembl peptide - ENSMUSP00000115078
Ensembl peptide - ENSMUSP00000115223
Ensembl peptide - ENSMUSP00000115591
Ensembl peptide - ENSMUSP00000119287
Ensembl peptide - ENSMUSP00000119803
NCBI entrez gene - 225115     See in Manteia.
MGI - MGI:2147319
RefSeq - XM_017317865
RefSeq - XM_011246877
RefSeq - XM_011246878
RefSeq - XM_011246879
RefSeq - XM_011246880
RefSeq - XM_011246881
RefSeq - XM_011246882
RefSeq - XM_011246883
RefSeq - XM_011246884
RefSeq - XM_011246885
RefSeq - NM_001347449
RefSeq - NM_153153
RefSeq - XM_006525789
RefSeq - XM_006525790
RefSeq - XM_006525791
RefSeq - XM_006525792
RefSeq - XM_006525793
RefSeq - XM_006525794
RefSeq - XM_006525800
RefSeq - XM_006525801
RefSeq - XM_011246876
RefSeq Peptide - NP_694793
RefSeq Peptide - NP_001334378
swissprot - F6TBK9
swissprot - D3Z2X9
swissprot - Q8K4L3
swissprot - A0A1B0GS91
swissprot - E9Q3Z5
swissprot - Q8K4L2
swissprot - F6R6A4
Ensembl - ENSMUSG00000024236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 svilaENSDARG00000055075Danio rerio
 SVILENSGALG00000007331Gallus gallus
 SVILENSG00000197321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vil1 / Q62468 / villin 1 / P09327*ENSMUSG0000002617511
Flii / Q9JJ28 / isoform 2 / Q13045* / FLII, actin remodeling protein*ENSMUSG0000000281211
Avil / O88398 / Advillin / O75366*ENSMUSG0000002543211
Vill / Q91YD6 / villin-like / O15195*ENSMUSG0000003877510
Gsn / P13020 / gelsolin / P06396*ENSMUSG000000268799
Scin / Q60604 / scinderin / Q9Y6U3*ENSMUSG000000025659
Capg / capping actin protein, gelsolin like / P40121*ENSMUSG000000567374


Protein motifs (from Interpro)
Interpro ID Name
 IPR003128  Villin headpiece
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR015628  Supervillin
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR036886  Villin headpiece domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007519 skeletal muscle tissue development ISO
 biological_processGO:0032467 positive regulation of cytokinesis ISS
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030496 midbody ISS
 cellular_componentGO:0032154 cleavage furrow ISS
 cellular_componentGO:0036449 microtubule minus-end ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043034 costamere ISO
 cellular_componentGO:0071437 invadopodium IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0051015 actin filament binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nabp2tm1.2Kkha/Nabp2tm1.2Kkha
Genetic Background: involves: BALB/cJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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