ENSMUSG00000002565


Mus musculus

Features
Gene ID: ENSMUSG00000002565
  
Biological name :Scin
  
Synonyms : Q60604 / Scin / scinderin
  
Possible biological names infered from orthology : Q9Y6U3
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: B1
Gene start: 40059769
Gene end: 40134228
  
Corresponding Affymetrix probe sets: 10400072 (MoGene1.0st)   1450276_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002640
Ensembl peptide - ENSMUSP00000077573
NCBI entrez gene - 20259     See in Manteia.
MGI - MGI:1306794
RefSeq - NM_001146196
RefSeq - NM_009132
RefSeq Peptide - NP_001139668
RefSeq Peptide - NP_033158
swissprot - Q60604
Ensembl - ENSMUSG00000002565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scinENSDARG00000010728Danio rerio
 SCINENSGALG00000010770Gallus gallus
 SCINENSG00000006747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsn / P13020 / gelsolin / P06396*ENSMUSG0000002687960
Avil / O88398 / Advillin / O75366*ENSMUSG0000002543248
Vil1 / Q62468 / villin 1 / P09327*ENSMUSG0000002617547
Vill / Q91YD6 / villin-like / O15195*ENSMUSG0000003877536
Flii / Q9JJ28 / isoform 2 / Q13045* / FLII, actin remodeling protein*ENSMUSG0000000281230
Svil / Q8K4L3 / supervillin / O95425*ENSMUSG0000002423628
Capg / capping actin protein, gelsolin like / P40121*ENSMUSG0000005673722


Protein motifs (from Interpro)
Interpro ID Name
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR030012  Adseverin
 IPR036180  Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0032330 regulation of chondrocyte differentiation ISS
 biological_processGO:0042989 sequestering of actin monomers ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation ISO
 biological_processGO:0051014 actin filament severing ISO
 biological_processGO:0051127 positive regulation of actin nucleation ISO
 biological_processGO:0051693 actin filament capping ISO
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx4tm4b(EUCOMM)Wtsi/Tbx4+
Genetic Background: C57BL/6N-Tbx4tm4b(EUCOMM)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr