ENSG00000006747


Homo sapiens

Features
Gene ID: ENSG00000006747
  
Biological name :SCIN
  
Synonyms : Q9Y6U3 / SCIN / scinderin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p21.3
Gene start: 12570577
Gene end: 12660179
  
Corresponding Affymetrix probe sets: 1552365_at (Human Genome U133 Plus 2.0 Array)   1552367_a_at (Human Genome U133 Plus 2.0 Array)   222272_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404380
Ensembl peptide - ENSP00000411149
Ensembl peptide - ENSP00000430997
Ensembl peptide - ENSP00000429598
Ensembl peptide - ENSP00000428555
Ensembl peptide - ENSP00000297029
Ensembl peptide - ENSP00000341375
NCBI entrez gene - 85477     See in Manteia.
OMIM - 613416
RefSeq - NM_033128
RefSeq - NM_001112706
RefSeq Peptide - NP_001106177
RefSeq Peptide - NP_149119
swissprot - E5RHX6
swissprot - Q9Y6U3
swissprot - E5RHN8
swissprot - C9JGB6
swissprot - F8WBX5
Ensembl - ENSG00000006747
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scinENSDARG00000010728Danio rerio
 SCINENSGALG00000010770Gallus gallus
 ScinENSMUSG00000002565Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSN / P06396 / gelsolinENSG0000014818060
AVIL / O75366 / advillinENSG0000013540749
VIL1 / P09327 / villin 1ENSG0000012783148
VILL / O15195 / villin likeENSG0000013605939
FLII / Q13045 / FLII, actin remodeling proteinENSG0000017773130
SVIL / O95425 / supervillinENSG0000019732128
CAPG / P40121 / capping actin protein, gelsolin likeENSG0000004249323


Protein motifs (from Interpro)
Interpro ID Name
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR030012  Adseverin
 IPR036180  Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0017156 calcium ion regulated exocytosis ISS
 biological_processGO:0032330 regulation of chondrocyte differentiation ISS
 biological_processGO:0042989 sequestering of actin monomers IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045010 actin nucleation ISS
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IMP
 biological_processGO:0051014 actin filament severing IMP
 biological_processGO:0051047 positive regulation of secretion ISS
 biological_processGO:0051127 positive regulation of actin nucleation IMP
 biological_processGO:0051693 actin filament capping IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001786 phosphatidylserine binding ISS
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005545 1-phosphatidylinositol binding TAS
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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