ENSG00000127831


Homo sapiens

Features
Gene ID: ENSG00000127831
  
Biological name :VIL1
  
Synonyms : P09327 / VIL1 / villin 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 218419092
Gene end: 218453295
  
Corresponding Affymetrix probe sets: 1554943_at (Human Genome U133 Plus 2.0 Array)   1554945_x_at (Human Genome U133 Plus 2.0 Array)   205506_at (Human Genome U133 Plus 2.0 Array)   228912_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394030
Ensembl peptide - ENSP00000412657
Ensembl peptide - ENSP00000409270
Ensembl peptide - ENSP00000248444
Ensembl peptide - ENSP00000375962
NCBI entrez gene - 7429     See in Manteia.
OMIM - 193040
RefSeq - NM_007127
RefSeq Peptide - NP_009058
swissprot - C9J2B5
swissprot - B4DV78
swissprot - H7C0B6
swissprot - P09327
Ensembl - ENSG00000127831
  
Related genetic diseases (OMIM): 193040 - Cholestasis, progressive canalicular
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vil1ENSDARG00000040466Danio rerio
 VIL1ENSGALG00000037286Gallus gallus
 Vil1ENSMUSG00000026175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AVIL / O75366 / advillinENSG0000013540761
VILL / O15195 / villin likeENSG0000013605948
GSN / P06396 / gelsolinENSG0000014818044
SCIN / Q9Y6U3 / scinderinENSG0000000674741
SVIL / O95425 / supervillinENSG0000019732128
FLII / Q13045 / FLII, actin remodeling proteinENSG0000017773125
CAPG / P40121 / capping actin protein, gelsolin likeENSG0000004249318


Protein motifs (from Interpro)
Interpro ID Name
 IPR003128  Villin headpiece
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR030007  Villin
 IPR036180  Gelsolin-like domain superfamily
 IPR036886  Villin headpiece domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001951 intestinal D-glucose absorption IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0030041 actin filament polymerization IDA
 biological_processGO:0030042 actin filament depolymerization IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IMP
 biological_processGO:0030855 epithelial cell differentiation IEP
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IDA
 biological_processGO:0032532 regulation of microvillus length IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0051014 actin filament severing IEA
 biological_processGO:0051016 barbed-end actin filament capping IMP
 biological_processGO:0051125 regulation of actin nucleation IDA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0060327 cytoplasmic actin-based contraction involved in cell motility IDA
 biological_processGO:0061041 regulation of wound healing ISS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:1902896 terminal web assembly IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2000392 regulation of lamellipodium morphogenesis ISS
 biological_processGO:2000394 positive regulation of lamellipodium morphogenesis IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005903 brush border ISS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0032432 actin filament bundle IDA
 cellular_componentGO:0032433 filopodium tip ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0035727 lysophosphatidic acid binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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