ENSMUSG00000026175


Mus musculus

Features
Gene ID: ENSMUSG00000026175
  
Biological name :Vil1
  
Synonyms : Q62468 / Vil1 / villin 1
  
Possible biological names infered from orthology : P09327
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 74409376
Gene end: 74435559
  
Corresponding Affymetrix probe sets: 10347364 (MoGene1.0st)   1448837_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027366
Ensembl peptide - ENSMUSP00000123786
NCBI entrez gene - 22349     See in Manteia.
MGI - MGI:98930
RefSeq - NM_009509
RefSeq Peptide - NP_033535
swissprot - F6V2H5
swissprot - Q62468
Ensembl - ENSMUSG00000026175
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vil1ENSDARG00000040466Danio rerio
 VIL1ENSGALG00000037286Gallus gallus
 VIL1ENSG00000127831Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Avil / O88398 / Advillin / O75366*ENSMUSG0000002543259
Vill / Q91YD6 / villin-like / O15195*ENSMUSG0000003877546
Gsn / P13020 / gelsolin / P06396*ENSMUSG0000002687943
Scin / Q60604 / scinderin / Q9Y6U3*ENSMUSG0000000256541
Svil / Q8K4L3 / supervillin / O95425*ENSMUSG0000002423628
Flii / Q9JJ28 / isoform 2 / Q13045* / FLII, actin remodeling protein*ENSMUSG0000000281225
Capg / capping actin protein, gelsolin like / P40121*ENSMUSG0000005673718


Protein motifs (from Interpro)
Interpro ID Name
 IPR003128  Villin headpiece
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR030007  Villin
 IPR036180  Gelsolin-like domain superfamily
 IPR036886  Villin headpiece domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001951 intestinal D-glucose absorption IGI
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030042 actin filament depolymerization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IEA
 biological_processGO:0032532 regulation of microvillus length IGI
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0040018 positive regulation of multicellular organism growth IGI
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0051014 actin filament severing IEA
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051125 regulation of actin nucleation IEA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0060327 cytoplasmic actin-based contraction involved in cell motility IEA
 biological_processGO:0061041 regulation of wound healing IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:1902896 terminal web assembly IGI
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IGI
 biological_processGO:2000392 regulation of lamellipodium morphogenesis IDA
 biological_processGO:2000394 positive regulation of lamellipodium morphogenesis IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0032432 actin filament bundle IEA
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0035727 lysophosphatidic acid binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

Allelic Composition: Hprttm2(CAG-mCherry/Villin*)Syr/?,Vil1tm1Syr/Vil1tm1Syr,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli1tm2Alj/Gli1tm2Alj,Gli2tm1Alj/Gli2+
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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