ENSMUSG00000056737


Mus musculus

Features
Gene ID: ENSMUSG00000056737
  
Biological name :Capg
  
Synonyms : Capg / capping actin protein, gelsolin like
  
Possible biological names infered from orthology : P40121
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 72544391
Gene end: 72562983
  
Corresponding Affymetrix probe sets: 10539135 (MoGene1.0st)   1447803_x_at (Mouse Genome 430 2.0 Array)   1450355_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109706
Ensembl peptide - ENSMUSP00000121221
Ensembl peptide - ENSMUSP00000121121
Ensembl peptide - ENSMUSP00000120363
Ensembl peptide - ENSMUSP00000118022
Ensembl peptide - ENSMUSP00000117440
Ensembl peptide - ENSMUSP00000063389
Ensembl peptide - ENSMUSP00000109705
NCBI entrez gene - 12332     See in Manteia.
MGI - MGI:1098259
RefSeq - XM_017321370
RefSeq - NM_001042534
RefSeq - NM_001271395
RefSeq - NM_001271415
RefSeq - NM_007599
RefSeq Peptide - NP_001258344
RefSeq Peptide - NP_031625
RefSeq Peptide - NP_001035999
RefSeq Peptide - NP_001258324
swissprot - D3YTL5
swissprot - D3Z014
swissprot - D3YZN3
swissprot - D3YU77
swissprot - Q99LB4
swissprot - D3Z4K5
Ensembl - ENSMUSG00000056737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capgaENSDARG00000035560Danio rerio
 capgbENSDARG00000099672Danio rerio
 CAPGENSG00000042493Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsn / P13020 / gelsolin / P06396*ENSMUSG0000002687950
Scin / Q60604 / scinderin / Q9Y6U3*ENSMUSG0000000256546
Avil / O88398 / Advillin / O75366*ENSMUSG0000002543242
Vil1 / Q62468 / villin 1 / P09327*ENSMUSG0000002617542
Vill / Q91YD6 / villin-like / O15195*ENSMUSG0000003877536
Flii / Q9JJ28 / isoform 2 / Q13045* / FLII, actin remodeling protein*ENSMUSG0000000281232
Svil / Q8K4L3 / supervillin / O95425*ENSMUSG0000002423628


Protein motifs (from Interpro)
Interpro ID Name
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR029917  Macrophage-capping protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051016 barbed-end actin filament capping IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Capgtm1Djk/Capgtm1Djk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capgtm1Djk/Capgtm1Djk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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