ENSMUSG00000002812


Mus musculus

Features
Gene ID: ENSMUSG00000002812
  
Biological name :Flii
  
Synonyms : Flii / isoform 2 / Q9JJ28
  
Possible biological names infered from orthology : FLII, actin remodeling protein / Q13045
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 60714123
Gene end: 60727263
  
Corresponding Affymetrix probe sets: 10386551 (MoGene1.0st)   1416044_at (Mouse Genome 430 2.0 Array)   1439356_at (Mouse Genome 430 2.0 Array)   1448189_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002889
NCBI entrez gene - 14248     See in Manteia.
MGI - MGI:1342286
RefSeq - NM_022009
RefSeq - NM_001302207
RefSeq Peptide - NP_001289136
RefSeq Peptide - NP_071292
swissprot - Q9JJ28
Ensembl - ENSMUSG00000002812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fliiENSDARG00000059701Danio rerio
 FLIIENSGALG00000004997Gallus gallus
 FLIIENSG00000177731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Svil / Q8K4L3 / supervillin / O95425*ENSMUSG0000002423619
Avil / O88398 / Advillin / O75366*ENSMUSG0000002543218
Scin / Q60604 / scinderin / Q9Y6U3*ENSMUSG0000000256517
Gsn / P13020 / gelsolin / P06396*ENSMUSG0000002687917
Vil1 / Q62468 / villin 1 / P09327*ENSMUSG0000002617516
Vill / Q91YD6 / villin-like / O15195*ENSMUSG0000003877514
Capg / capping actin protein, gelsolin like / P40121*ENSMUSG000000567379


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR025875  Leucine rich repeat 4
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR029919  Protein flightless-1
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036180  Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0051014 actin filament severing TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Smad2tm1Rak/Smad2tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Smad2tm1Rak/Smad2tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Smad2tm1Rak/Smad2tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr