ENSGALG00000001446


Gallus gallus

Features
Gene ID: ENSGALG00000001446
  
Biological name :GSN
  
Synonyms : gelsolin precursor / GSN
  
Possible biological names infered from orthology : gelsolin / P06396 / P13020
  
Species: Gallus gallus
  
Chr. number: 17
Strand: 1
Band:
Gene start: 8882615
Gene end: 8908331
  
Corresponding Affymetrix probe sets: Gga.4451.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002197
Ensembl peptide - ENSGALP00000064038
Ensembl peptide - ENSGALP00000054518
Ensembl peptide - ENSGALP00000052108
NCBI entrez gene - 395774     See in Manteia.
RefSeq - XM_015279327
RefSeq - XM_015279330
RefSeq - XM_015279329
RefSeq - XM_015279328
RefSeq - NM_204934
RefSeq Peptide - NP_990265
swissprot - A0A1L1RYW9
swissprot - F1NKF3
swissprot - A0A1D5PH32
swissprot - A0A1D5PNS4
Ensembl - ENSGALG00000001446
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsnaENSDARG00000011459Danio rerio
 gsnbENSDARG00000045262Danio rerio
 GSNENSG00000148180Homo sapiens
 GsnENSMUSG00000026879Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SCIN / adseverin / Q60604* / Q9Y6U3* / scinderin*ENSGALG0000001077053
VIL1 / villin-1 / P09327* / Q62468*ENSGALG0000003728643
VILL / villin like / O15195* / Q91YD6*ENSGALG0000000576339
FLII / protein flightless-1 homolog / Q13045* / Q9JJ28* / isoform 2 * / FLII, actin remodeling protein*ENSGALG0000000499727
SVIL / supervillin / O95425* / Q8K4L3*ENSGALG0000000733124


Protein motifs (from Interpro)
Interpro ID Name
 IPR007122  Villin/Gelsolin
 IPR007123  Gelsolin-like domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR030004  Gelsolin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006911 phagocytosis, engulfment IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014891 striated muscle atrophy IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0042989 sequestering of actin monomers IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IEA
 biological_processGO:0051014 actin filament severing IEA
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051127 positive regulation of actin nucleation IEA
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071801 regulation of podosome assembly IEA
 biological_processGO:0090527 actin filament reorganization IEA
 biological_processGO:0097017 renal protein absorption IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1902174 positive regulation of keratinocyte apoptotic process IEA
 biological_processGO:1903903 regulation of establishment of T cell polarity IEA
 biological_processGO:1903906 regulation of plasma membrane raft polarization IEA
 biological_processGO:1903909 regulation of receptor clustering IEA
 biological_processGO:1903923 positive regulation of protein processing in phagocytic vesicle IEA
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016528 sarcoplasm IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030478 actin cap IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0045159 myosin II binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction






 

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