ENSG00000074964


Homo sapiens

Features
Gene ID: ENSG00000074964
  
Biological name :ARHGEF10L
  
Synonyms : ARHGEF10L / Q9HCE6 / Rho guanine nucleotide exchange factor 10 like
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.13
Gene start: 17539835
Gene end: 17697874
  
Corresponding Affymetrix probe sets: 1570511_at (Human Genome U133 Plus 2.0 Array)   221656_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000167825
Ensembl peptide - ENSP00000355060
Ensembl peptide - ENSP00000364557
Ensembl peptide - ENSP00000364564
NCBI entrez gene - 55160     See in Manteia.
OMIM - 612494
RefSeq - XM_017001622
RefSeq - NM_001011722
RefSeq - NM_001319837
RefSeq - NM_001319838
RefSeq - NM_001328124
RefSeq - NM_018125
RefSeq - XM_011541695
RefSeq - XM_011541696
RefSeq - XM_017001617
RefSeq - XM_017001618
RefSeq - XM_017001619
RefSeq - XM_017001620
RefSeq - XM_017001621
RefSeq - XM_005245923
RefSeq - XM_005245925
RefSeq - XM_005245927
RefSeq - XM_005245929
RefSeq - XM_006710728
RefSeq - XM_006710729
RefSeq - XM_006710731
RefSeq - XM_011541691
RefSeq - XM_011541692
RefSeq - XM_011541693
RefSeq Peptide - NP_060595
RefSeq Peptide - NP_001306767
RefSeq Peptide - NP_001315053
RefSeq Peptide - NP_001306766
RefSeq Peptide - NP_001011722
swissprot - Q9HCE6
swissprot - Q5VXI4
Ensembl - ENSG00000074964
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef10laENSDARG00000088630Danio rerio
 arhgef10lbENSDARG00000074244Danio rerio
 ARHGEF10LENSGALG00000043128Gallus gallus
 A2AWP8ENSMUSG00000040964Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15013 / ARHGEF10 / Rho guanine nucleotide exchange factor 10ENSG0000010472844
Q96PE2 / ARHGEF17 / Rho guanine nucleotide exchange factor 17ENSG0000011023721
SPAG9 / O60271 / sperm associated antigen 9ENSG0000000829414
Q9UPT6 / MAPK8IP3 / mitogen-activated protein kinase 8 interacting protein 3ENSG0000013883414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR011993  PH-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032933 SREBP signaling pathway IDA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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