ENSMUSG00000022663


Mus musculus

Features
Gene ID: ENSMUSG00000022663
  
Biological name :Atg3
  
Synonyms : Atg3 / Q9CPX6 / Ubiquitin-like-conjugating enzyme ATG3
  
Possible biological names infered from orthology : autophagy related 3 / Q9NT62
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B5
Gene start: 45158785
Gene end: 45188538
  
Corresponding Affymetrix probe sets: 10435963 (MoGene1.0st)   1418179_at (Mouse Genome 430 2.0 Array)   1448993_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023343
NCBI entrez gene - 67841     See in Manteia.
MGI - MGI:1915091
RefSeq - NM_026402
RefSeq - XM_006522495
RefSeq Peptide - NP_080678
swissprot - Q9CPX6
Ensembl - ENSMUSG00000022663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg3ENSDARG00000009350Danio rerio
 ATG3ENSGALG00000015204Gallus gallus
 ATG3ENSG00000144848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007134  Autophagy-related protein 3, N-terminal
 IPR007135  Autophagy-related protein 3
 IPR019461  Autophagy-related protein 3, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000422 autophagy of mitochondrion IBA
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016236 macroautophagy IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IMP
 biological_processGO:0044804 autophagy of nucleus IBA
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 cellular_componentGO:0000153 cytoplasmic ubiquitin ligase complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019776 Atg8 ligase activity IMP
 molecular_functionGO:0019777 Atg12 transferase activity IDA
 molecular_functionGO:0019787 ubiquitin-like protein transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Ephx2tm1.1Arte/Ephx2tm1.1Arte,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nalcnem1Iiis/Nalcn+
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg3tm1Kmts/Atg3tm1Kmts
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Atg3tm1Kmts/Atg3+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Atg3tm1.1Ywh/Atg3tm1.1Ywh,Fnip1m1Btlr/Fnip1m1Btlr,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Atg3tm1Kmts/Atg3tm1Kmts
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg3tm1Kmts/Atg3tm1Kmts
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Atg3tm1Kmts/Atg3tm1Kmts
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026289 Q8C0J2 / Atg16l1 / autophagy related 16-like 1 (S. cerevisiae) / Q676U5* / autophagy related 16 like 1*  / reaction
 ENSMUSG00000030314 Atg7 / Q9D906 / Ubiquitin-like modifier-activating enzyme ATG7 / O95352* / autophagy related 7*  / reaction / complex






 

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