ENSMUSG00000030314


Mus musculus

Features
Gene ID: ENSMUSG00000030314
  
Biological name :Atg7
  
Synonyms : Atg7 / Q9D906 / Ubiquitin-like modifier-activating enzyme ATG7
  
Possible biological names infered from orthology : autophagy related 7 / O95352
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 114643097
Gene end: 114860614
  
Corresponding Affymetrix probe sets: 10540860 (MoGene1.0st)   1428610_at (Mouse Genome 430 2.0 Array)   1428611_at (Mouse Genome 430 2.0 Array)   1428612_at (Mouse Genome 430 2.0 Array)   1446633_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138779
Ensembl peptide - ENSMUSP00000138651
Ensembl peptide - ENSMUSP00000138731
Ensembl peptide - ENSMUSP00000032457
Ensembl peptide - ENSMUSP00000133215
Ensembl peptide - ENSMUSP00000138137
Ensembl peptide - ENSMUSP00000138253
Ensembl peptide - ENSMUSP00000138300
Ensembl peptide - ENSMUSP00000138358
Ensembl peptide - ENSMUSP00000138374
Ensembl peptide - ENSMUSP00000138404
Ensembl peptide - ENSMUSP00000138600
NCBI entrez gene - 74244     See in Manteia.
MGI - MGI:1921494
RefSeq - XM_011241495
RefSeq - NM_001253717
RefSeq - NM_001253718
RefSeq - NM_028835
RefSeq - XM_006506707
RefSeq - XM_006506708
RefSeq - XM_006506709
RefSeq - XM_006506710
RefSeq - XM_011241494
RefSeq Peptide - NP_083111
RefSeq Peptide - NP_001240646
RefSeq Peptide - NP_001240647
swissprot - S4R1W9
swissprot - S4R2D5
swissprot - S4R2P7
swissprot - S4R2T5
swissprot - A0A0A0MQN4
swissprot - Q9D906
swissprot - S4R1N8
swissprot - S4R1K1
swissprot - S4R1T0
swissprot - S4R1U3
Ensembl - ENSMUSG00000030314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg7ENSDARG00000102893Danio rerio
 ATG7ENSGALG00000004932Gallus gallus
 ATG7ENSG00000197548Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR006285  Ubiquitin-like modifier-activating enzyme Atg7
 IPR032197  Ubiquitin-like modifier-activating enzyme Atg7, N-terminal
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000422 autophagy of mitochondrion ISO
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006497 protein lipidation ISO
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0006996 organelle organization IMP
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0009267 cellular response to starvation ISS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016236 macroautophagy ISO
 biological_processGO:0019725 cellular homeostasis IMP
 biological_processGO:0021680 cerebellar Purkinje cell layer development IMP
 biological_processGO:0021860 pyramidal neuron development IMP
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0031396 regulation of protein ubiquitination IMP
 biological_processGO:0031401 positive regulation of protein modification process ISO
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032446 protein modification by small protein conjugation IMP
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0034727 piecemeal microautophagy of the nucleus IBA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0039521 suppression by virus of host autophagy ISO
 biological_processGO:0039689 negative stranded viral RNA replication IMP
 biological_processGO:0042594 response to starvation IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0044805 late nucleophagy IBA
 biological_processGO:0045732 positive regulation of protein catabolic process ISS
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:0050877 nervous system process IMP
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0060284 regulation of cell development IMP
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0061024 membrane organization IMP
 biological_processGO:0070257 positive regulation of mucus secretion IMP
 biological_processGO:0071315 cellular response to morphine IEA
 biological_processGO:0071455 cellular response to hyperoxia ISS
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont ISO
 biological_processGO:0080144 amino acid homeostasis IMP
 biological_processGO:0090156 cellular sphingolipid homeostasis IMP
 biological_processGO:0090298 negative regulation of mitochondrial DNA replication IEA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:1902617 response to fluoride IEA
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IEA
 biological_processGO:1903706 regulation of hemopoiesis IMP
 biological_processGO:2000619 negative regulation of histone H4-K16 acetylation IMP
 cellular_componentGO:0000407 phagophore assembly site IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0030424 axon IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0019778 Atg12 activating enzyme activity IMP
 molecular_functionGO:0019779 Atg8 activating enzyme activity IDA
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
Macroautophagy
Neutrophil degranulation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Pfn1tm1Foxp/Pfn1tm1Foxp,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6NTac

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc2tm1Djk/Tsc2+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * DBA/2

Allelic Composition: Tsc2tm1Djk/Tsc2+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL * C57BL/6 * CBA/JNCrlj

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apctm2.1Cip/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msi1tm1.1(cre/ERT2)Njen/Msi1tm1.1(cre/ERT2)Njen
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Defa6-icre)1Rsb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003325 decreased liver function "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cfTg(Myh6-cre/Esr1*)1Jmk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Nes-cre)1Wme/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: BALB/c * C57BL * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Tsc2tm1Djk/Tsc2+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL * C57BL/6 * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: BALB/c * C57BL * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Tsc2tm1Djk/Tsc2+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL * C57BL/6 * CBA/JNCrlj

 MP:0009972 absent hippocampus pyramidal cells "absence of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Nes-cre)1Wme/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0009975 absent cerebral cortex pyramidal cells "increased number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Nes-cre)1Wme/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Sqstm1tm1Keta/Sqstm1tm1Keta,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: NsdhlBpa-6H/Nsdhl+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0012434 decreased intestinal adenoma incidence "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0013219 abnormal substantia nigra pars compacta morphology "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0013654 increased CD103-positive CD11b-low dendritic cell number "increase in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [MGI:Saran, PMID:23516985]
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Allelic Composition: Apctm2.1Cip/Apc+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2

 MP:0020395 abnormal response to social novelty "any anomaly in the interaction of an individual with a familiar versus a novel individual of the same species; in mouse the typical behavior is is for increased interaction with the novel individual" [PMID:23280234]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: BALB/c * C57BL * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Tsc2tm1Djk/Tsc2+,Atg7tm1Tchi/Atg7tm1Tchi,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL * C57BL/6 * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022663 Atg3 / Q9CPX6 / Ubiquitin-like-conjugating enzyme ATG3 / Q9NT62* / autophagy related 3*  / reaction / complex
 ENSMUSG00000030314 Atg7 / Q9D906 / Ubiquitin-like modifier-activating enzyme ATG7 / O95352* / autophagy related 7*  / complex
 ENSMUSG00000032905 Atg12 / Q9CQY1 / Ubiquitin-like protein ATG12 / O94817* / autophagy related 12*  / reaction / complex






 

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